MAPK cell-cycle regulation in Saccharomyces cerevisiae and Candida albicans

Future Microbiology
Inês CorreiaJesús Pla

Abstract

The cell cycle is the sequential set of events that living cells undergo in order to duplicate. This process must be tightly regulated as alterations may lead to diseases such as cancer. The molecular events that control the cell cycle are directional and involve regulatory molecules such as cyclins and cyclin-dependent kinases (CDKs). The budding yeast Saccharomyces cerevisiae has become a model to study this complex system since it shares several mechanisms with higher eukaryotes. Signal transduction pathways are biochemical mechanisms that sense environmental changes and there is recent evidence that they control the progression through the cell cycle in response to several stimuli. In response to pheromone, the budding yeast arrests the cell cycle in the G1 phase at the START stage. Activation of the pheromone response pathway leads to the phosphorylation of Far1, which inhibits the function of complexes formed by G1 cyclins (Cln1 and Cln2) and the CDK (Cdc28), blocking the transition to the S phase. This response prepares the cells to fuse cytoplasms and nuclei to generate a diploid cell. Activation of the Hog1 MAP kinase in response to osmotic stress or arsenite leads to the transient arrest of the cell cycle in G1 phase,...Continue Reading

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Citations

Aug 4, 2012·PloS One·David Quinto-AlemanyCristina Gil-Lamaignere
Jan 19, 2016·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Xin SunCai-Yun Zhong
Nov 29, 2011·Current Opinion in Biotechnology·Abderahmane DerouicheIvan Mijakovic
Feb 20, 2018·Fungal biology and biotechnology·Zinnat ShahinaTanya E S Dahms
Jul 28, 2017·Cellular Oncology (Dordrecht)·Georgios S MarkopoulosEvangelos Kolettas
Apr 11, 2020·Virulence·Hui ChenLei Cheng
Feb 16, 2021·Critical Reviews in Microbiology·Hui LuYuanying Jiang
Oct 3, 2019·Plant Physiology·Zaizhi YouXiaoling Miao

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Methods Mentioned

BETA
ubiquitination

Software Mentioned

BLAST

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