MAPK-dependent hormonal signaling plasticity contributes to overcoming Bacillus thuringiensis toxin action in an insect host.

Nature Communications
Zhaojiang GuoYoujun Zhang

Abstract

The arms race between entomopathogenic bacteria and their insect hosts is an excellent model for decoding the intricate coevolutionary processes of host-pathogen interaction. Here, we demonstrate that the MAPK signaling pathway is a general switch to trans-regulate differential expression of aminopeptidase N and other midgut genes in an insect host, diamondback moth (Plutella xylostella), thereby countering the virulence effect of Bacillus thuringiensis (Bt) toxins. Moreover, the MAPK cascade is activated and fine-tuned by the crosstalk between two major insect hormones, 20-hydroxyecdysone (20E) and juvenile hormone (JH) to elicit an important physiological response (i.e. Bt resistance) without incurring the significant fitness costs often associated with pathogen resistance. Hormones are well known to orchestrate physiological trade-offs in a wide variety of organisms, and our work decodes a hitherto undescribed function of these classic hormones and suggests that hormonal signaling plasticity is a general cross-kingdom strategy to fend off pathogens.

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Citations

Jan 29, 2021·Microbiology and Molecular Biology Reviews : MMBR·Daniel PinosPatricia Hernández-Martínez
Mar 2, 2021·Frontiers in Microbiology·Jizhen WeiShiheng An
Jul 3, 2021·International Journal of Molecular Sciences·Jianying QinZhaojiang Guo

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Datasets Mentioned

BETA
AAB70755
CAA66467
AAF01259
CAA10950

Methods Mentioned

BETA
RNA-Seq
PCR
electrophoresis
transfection
gene knockout
genotyping

Software Mentioned

POLO Plus
LeOra
ImageJ
MassLynx
big
DNAMAN
WebLogo
TMHMM
blastn
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