MAPK/ERK Signaling in Regulation of Renal Differentiation

International Journal of Molecular Sciences
Kristen KurtzebornSatu Kuure

Abstract

Congenital anomalies of the kidney and urinary tract (CAKUT) are common birth defects derived from abnormalities in renal differentiation during embryogenesis. CAKUT is the major cause of end-stage renal disease and chronic kidney diseases in children, but its genetic causes remain largely unresolved. Here we discuss advances in the understanding of how mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) activity contributes to the regulation of ureteric bud branching morphogenesis, which dictates the final size, shape, and nephron number of the kidney. Recent studies also demonstrate that the MAPK/ERK pathway is directly involved in nephrogenesis, regulating both the maintenance and differentiation of the nephrogenic mesenchyme. Interestingly, aberrant MAPK/ERK signaling is linked to many cancers, and recent studies suggest it also plays a role in the most common pediatric renal cancer, Wilms' tumor.

References

Aug 28, 2019·International Journal of Molecular Sciences·Giovanna CapolongoMiriam Zacchia
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Related Concepts

Study
Size
Regulation of Biological Process
Branching Involved in Ureteric Bud Morphogenesis
Kidney
Embryonic Development
Cell Differentiation Process
Birth
DSTYK
Kidney Failure, Chronic

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