Mapping a blood pressure quantitative trait locus to a 5.7-cM region in Dahl salt-sensitive rats

Mammalian Genome : Official Journal of the International Mammalian Genome Society
Julie Dutil, A Y Deng

Abstract

A region on rat Chromosome (Chr) 2 of the Dahl salt-sensitive rat (S) was shown previously to contain a quantitative trait locus (QTL) for blood pressure (BP). This was achieved first by linkage, followed by the use of congenic strains. A congenic strain, designated S.MNS-D2Mit6/Adh, contained a segment of Chr 2 from the Milan Normotensive (MNS) rat in the S genetic background. Since the region containing the QTL was roughly 80 cM in size, a further reduction was needed towards the positional or candidate gene cloning. Currently, two congenic substrains were made from the original strain S.MNS-D2Mit6/Adh. One of these two substrains showed a BP-lowering effect, whereas the other substrain did not. Deducing the segment not shared in the two substrains, the BP QTL has to be present in a chromosome region of roughly 5.7 cM between the marker D2Rat303 and the locus for the neutroendopeptidase gene (Nep). Nep is not included within the segment. This region does not seem to contain any candidate genes well known for the BP control. Thus, the final identification of the QTL will most likely lead to the discovery of a brand new gene for the BP regulation.

Citations

Apr 15, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Myriam MoujahidineAlan Y Deng
Nov 7, 2012·Journal of the American Heart Association·Bina Joe, Joseph I Shapiro
Mar 8, 2003·Hypertension·Martin W McBrideAnna F Dominiczak
Dec 5, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Chenda DuongAlan Y Deng

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