Mapping alterations of gray matter volume and white matter integrity in children with autism spectrum disorder: evidence from fMRI findings

Neuroreport
Qun YangLong-Biao Cui

Abstract

This study aimed to identify the neuroanatomical substrates and white matter connectivity in children with autism spectrum disorder (ASD) and the association between gray matter and structural connectivity. A total of 36 children including patients with ASD and healthy controls between 6 and 15 years of age were enrolled in this study. High-resolution structural MRI and functional MRI were performed and analyzed using voxel-based morphometry and tract-based spatial statistics. The relationship between gray matter volume and structural connectivity was generated using Pearson correlation analysis. Voxel-based morphometry analysis showed significantly reduced areas of gray matter in the left cerebellum. Tract-based spatial statistics analysis showed white matter abnormalities in several distinct clusters within the right inferior frontal gyrus (opercular part), the left inferior parietal lobule, and the right mentary motor area. Neither ASD nor healthy controls showed a significant correlation between gray matter volume and white matter integrity. Our study confirmed the presence of several structural and regional abnormalities in ASD children. These findings suggest that there are significant differences in some brain regions in...Continue Reading

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Citations

Aug 1, 2021·Pediatric Neurology·Daniel E Lidstone, Stewart H Mostofsky
Oct 10, 2021·Journal of Magnetic Resonance Imaging : JMRI·Faranak RafieeIlyssa J Yousem

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Software Mentioned

Eddy Current Correction ( FSL
FSL
FLIRT
McFlirt FSL
FNIRT
DTIFit ( FMRIB Library Diffusion Toolbox
SPSS
TBSS
Brain Extraction Tool ( FSL

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