Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar)

Serap GonenRoss D Houston


Pancreas disease (PD), caused by a salmonid alphavirus (SAV), has a large negative economic and animal welfare impact on Atlantic salmon aquaculture. Evidence for genetic variation in host resistance to this disease has been reported, suggesting that selective breeding may potentially form an important component of disease control. The aim of this study was to explore the genetic architecture of resistance to PD, using survival data collected from two unrelated populations of Atlantic salmon; one challenged with SAV as fry in freshwater (POP 1) and one challenged with SAV as post-smolts in sea water (POP 2). Analyses of the binary survival data revealed a moderate-to-high heritability for host resistance to PD in both populations (fry POP 1 h(2)~0.5; post-smolt POP 2 h(2)~0.4). Subsets of both populations were genotyped for single nucleotide polymorphism markers, and six putative resistance quantitative trait loci (QTL) were identified. One of these QTL was mapped to the same location on chromosome 3 in both populations, reaching chromosome-wide significance in both the sire- and dam-based analyses in POP 1, and genome-wide significance in a combined analysis in POP 2. This independently verified QTL explains a significant prop...Continue Reading


Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T P KeithC Hogan
Mar 1, 1972·Behavior Genetics·J K Haseman, R C Elston
Mar 27, 2007·Bioinformatics·Yurii S AulchenkoCornelia M van Duijn
Feb 25, 2009·Journal of Fish Diseases·D A GrahamH R Rowley
Jul 2, 2009·Genetics, Selection, Evolution : GSE·Anna Kristina Sonesson, Theo H E Meuwissen
Oct 5, 2010·Genome Biology·William S DavidsonStig W Omholt
Mar 9, 2012·Bioinformatics·Iman HajirasoulihaS Cenk Sahinalp
Jul 3, 2013·Veterinary Immunology and Immunopathology·Tharangani K HerathRandolph H Richards
Oct 1, 2013·Bioinformatics·Pasi RastasPetri Auvinen
Jul 1, 1996·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·S A KnottC S Haley
Nov 1, 1992·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·A Darvasi, M Soller


Sep 17, 2016·Journal of Fish Diseases·Q K DoanF Allal
Apr 5, 2018·International Journal of Molecular Sciences·Hetron Mweemba Munang'anduLior David
Feb 9, 2018·G3 : Genes - Genomes - Genetics·D RobledoRoss D Houston
Apr 28, 2019·Cells·Takuya Yamaguchi, Johannes M Dijkstra
Jul 10, 2019·The Journal of Heredity·S A BoisonN A Robinson
Apr 18, 2020·Nature Reviews. Genetics·Ross D HoustonD Robledo
Aug 29, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Victoria K Baxter, Mark T Heise
Feb 22, 2017·BMC Genomics·Aquaculture Genomics, Genetics and Breeding WorkshopTao Zhou

Related Concepts

Barmah Forest virus
Genome Mapping
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Single Nucleotide Polymorphism
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