Mapping and validation of a major QTL affecting resistance to pancreas disease (salmonid alphavirus) in Atlantic salmon (Salmo salar)

Heredity
Serap GonenRoss D Houston

Abstract

Pancreas disease (PD), caused by a salmonid alphavirus (SAV), has a large negative economic and animal welfare impact on Atlantic salmon aquaculture. Evidence for genetic variation in host resistance to this disease has been reported, suggesting that selective breeding may potentially form an important component of disease control. The aim of this study was to explore the genetic architecture of resistance to PD, using survival data collected from two unrelated populations of Atlantic salmon; one challenged with SAV as fry in freshwater (POP 1) and one challenged with SAV as post-smolts in sea water (POP 2). Analyses of the binary survival data revealed a moderate-to-high heritability for host resistance to PD in both populations (fry POP 1 h(2)~0.5; post-smolt POP 2 h(2)~0.4). Subsets of both populations were genotyped for single nucleotide polymorphism markers, and six putative resistance quantitative trait loci (QTL) were identified. One of these QTL was mapped to the same location on chromosome 3 in both populations, reaching chromosome-wide significance in both the sire- and dam-based analyses in POP 1, and genome-wide significance in a combined analysis in POP 2. This independently verified QTL explains a significant prop...Continue Reading

References

Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T P KeithC Hogan
Mar 1, 1972·Behavior Genetics·J K Haseman, R C Elston
Mar 27, 2007·Bioinformatics·Yurii S AulchenkoCornelia M van Duijn
Feb 25, 2009·Journal of Fish Diseases·D A GrahamH R Rowley
Jul 2, 2009·Genetics, Selection, Evolution : GSE·Anna Kristina Sonesson, Theo H E Meuwissen
Oct 5, 2010·Genome Biology·William S DavidsonStig W Omholt
Mar 9, 2012·Bioinformatics·Iman HajirasoulihaS Cenk Sahinalp
Jul 3, 2013·Veterinary Immunology and Immunopathology·Tharangani K HerathRandolph H Richards
Oct 1, 2013·Bioinformatics·Pasi RastasPetri Auvinen
Jul 1, 1996·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·S A KnottC S Haley
Nov 1, 1992·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·A Darvasi, M Soller

Citations

Sep 17, 2016·Journal of Fish Diseases·Q K DoanF Allal
Apr 5, 2018·International Journal of Molecular Sciences·Hetron Mweemba Munang'anduLior David
Feb 9, 2018·G3 : Genes - Genomes - Genetics·D RobledoRoss D Houston
Apr 28, 2019·Cells·Takuya Yamaguchi, Johannes M Dijkstra
Jul 10, 2019·The Journal of Heredity·S A BoisonN A Robinson
Apr 18, 2020·Nature Reviews. Genetics·Ross D HoustonD Robledo
Aug 29, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Victoria K Baxter, Mark T Heise
Feb 22, 2017·BMC Genomics·Aquaculture Genomics, Genetics and Breeding WorkshopTao Zhou

Related Concepts

Barmah Forest virus
Metazoa
Genome Mapping
Fish Diseases
Genetics, Population
Pancreatic Diseases
Salmo salar
Single Nucleotide Polymorphism
Inheritance Patterns
Quantitative Trait Loci

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Generating Insulin-Secreting Cells

Reprogramming cells or using induced pluripotent stem cells to generate insulin-secreting cells has significant therapeutic implications for diabetics. Here is the latest research on generation of insulin-secreting cells.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Epigenome Editing

Epigenome editing is the directed modification of epigenetic marks on chromatin at specified loci. This tool has many applications in research as well as in the clinic. Find the latest research on epigenome editing here.