Mapping brain function using a 30-day interval between baseline and activation: a novel arterial spin labeling fMRI approach.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Ajna BorogovacIris Asllani

Abstract

By comparing hemodynamic signals acquired immediately before and during activation, functional magnetic resonance imaging (fMRI) is well suited for mapping acute changes in brain function. However, it remains unclear whether fMRI can map functional changes over longer periods. Here, we address this issue by empirically testing the feasibility of arterial spin labeling (ASL) fMRI to detect changes in cerebral blood flow (CBF) with baseline and task separated by 1 month. To increase the sensitivity of the method, we applied an algorithm that yielded flow density (CBFd) images that were independent of tissue content. To increase the accuracy, we developed a technique that generated arterial transit time at each voxel, independently. Results showed that activation changes in CBFd during the same session were statistically the same as across 30 days. The activation CBFd on day-30 was 34% (motor) and 25% (visual) higher than the respective baselines of 83 and 107 mL/100 g/min obtained on day-1. Furthermore, the signal-to-noise ratio of the CBFd measurement was 2.1 and 2.9 times higher than that of the conventional CBF for within-subject and across-subjects comparisons, respectively (n=9 healthy young subjects). Taken together, these ...Continue Reading

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Citations

Sep 12, 2012·International Journal of Biomedical Imaging·Ajna Borogovac, Iris Asllani
Jan 3, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jan PetrJörg van den Hoff
Jul 18, 2016·Journal of the Neurological Sciences·Randolph S MarshallRonald M Lazar
Oct 11, 2017·Social Cognitive and Affective Neuroscience·Christian E WaughJoseph A Maldjian
Apr 17, 2018·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Feng LiuAlayar Kangarlu

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