Feb 1, 1996

Mapping guided laser catheter ablation of the atrioventricular conduction in dogs

Pacing and Clinical Electrophysiology : PACE
H P WeberE Unsöld


Safety and efficacy of mapping guided laser catheter ablation of the AV junction was tested in a canine model. A total of 43 laser pulses (continuous wave, Nd:YAG, 1,064 nm, 30 W, irradiated spot diameter 2.0-2.5 mm) were delivered in 15 dogs (2-5 per dog) via a novel laser catheter system. Pulses were selectively aimed at: (1) the AV node; (2) the His bundle; and (3) the bundle branches. Laser pulses of 9.7 +/- 1.1 seconds (n = 31) produced reversible conduction disturbances in the targeted segment of the AV conduction system, while pulses of 28.6 +/- 7.9 seconds (n = 9) resulted in chronic block. The dogs survived the procedure without complications. Follow-up was 6.5-10.5 months. Histopathologically, lesions showed clear-cut oval-shaped areas of fibrosis of 0.5-18.0 mm in diameter and 0.5-3.5 mm (transmural) in depth, depending on the irradiation time. Pervenous mapping guided laser catheter irradiation of the AV junction can produce AV block consistently and selectively in the targeted segment of the right ventricular conduction system in dogs. The method is safe and can be performed in a controllable manner by using the catheter system presented.

  • References16
  • Citations3


Mentioned in this Paper

Supraventricular Tachycardia
Heart Block
Physiologic Pulse
Left Bundle Branch of His
Atrioventricular Block
Fourier Transform
Body Surface Area Formula for Dogs
Signal Processing, Digital
Structure of Atrioventricular Node
Bundle of His

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