Dec 17, 2009

Mapping human genetic diversity in Asia

Science
Hugo Pan-Asian SNP ConsortiumIndian Genome Variation Consortium

Abstract

Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

  • References23
  • Citations250

References

  • References23
  • Citations250

Citations

Mentioned in this Paper

Labor Migration
Linguistics
Human Genetics
History, Ancient
Phylogeny
Human Geography
Korean Race
Porphyria, South African Type
Bayesian Prediction
Cdna Microarrays

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