Mapping immediate-early gene activity in the rat after place learning in a water-maze: the importance of matched control conditions.

The European Journal of Neuroscience
K L Shires, John P Aggleton

Abstract

The expression of two immediate-early genes (IEGs), Zif268 and c-Fos, was quantified in hippocampal subregions and related structures following spatial learning in the Morris water-maze. A critical feature was the novel control protocol alongside more standard controls, the purpose of which was to test whether hippocampal activity is set automatically when traversing an environment or whether it is dependent on reaching a specific goal using learning that requires the hippocampus (i.e. task dependent). The new control protocol (Procedural Task) made it possible to match swim time, swim distance and learning to escape from water with that of the experimental (Working Memory) group. Unlike the Working Memory group, the Procedural Task animals showed no evidence of learning the absolute platform location during the test session. While the Working Memory rats showed c-Fos increases relative to the Procedural Task controls in the frontal and parahippocampal cortices, hippocampal levels did not differ. Again, for Zif268 there was no evidence of a relative increase of hippocampal activity in the Working Memory group. In fact, hippocampal Zif268 showed evidence of a relative decrease, even though the spatial working memory task is hipp...Continue Reading

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Citations

Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Daniel G WoolleyRudi D'Hooge
Dec 29, 2015·Journal of Neurochemistry·Fabrizio CapitanoGiorgio Camilloni
Nov 15, 2011·Neuroscience and Biobehavioral Reviews·Michael A van der Kooij, Carmen Sandi
Jul 28, 2009·Neurobiology of Aging·Jason S SnyderHeather A Cameron
Jun 24, 2009·Physiology & Behavior·Magdalena Méndez-LópezJorge L Arias
Sep 13, 2013·Progress in Neurobiology·Jean-Christophe CasselRobert P Vertes
Jul 3, 2015·Frontiers in Behavioral Neuroscience·Sylvia D CarterJohannes M H M Reul
Jul 3, 2010·Behavioral and Brain Functions : BBF·Lisa A FeldmanJosephine Nalbantoglu
Mar 1, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Pablo Martín CassanelliSilvia Wikinski
Jan 14, 2017·PLoS Biology·Lisa GenzelRichard G M Morris
Mar 23, 2017·Frontiers in Behavioral Neuroscience·Florian Duclot, Mohamed Kabbaj
Oct 23, 2019·Behavior Research Methods·Sean ComminsConor Thornberry
Apr 12, 2011·Reviews in the Neurosciences·Daniel N Barry, Sean Commins
Feb 27, 2019·Journal of Neuroscience Methods·Daniel N Barry, Sean Commins

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