PMID: 24339736Dec 18, 2013Paper

Mapping in vivo tumor oxygenation within viable tumor by 19F-MRI and multispectral analysis

Neoplasia : an International Journal for Oncology Research
Yunzhou ShiRichard A D Carano

Abstract

Quantifying oxygenation in viable tumor remains a major obstacle toward a better understanding of the tumor micro-environment and improving treatment strategies. Current techniques are often complicated by tumor heterogeneity. Herein, a novel in vivo approach that combines (19)F magnetic resonance imaging ((19)F-MRI) R 1 mapping with diffusion-based multispectral (MS) analysis is introduced. This approach restricts the partial pressure of oxygen (pO2) measurements to viable tumor, the tissue of therapeutic interest. The technique exhibited sufficient sensitivity to detect a breathing gas challenge in a xenograft tumor model, and the hypoxic region measured by MS (19)F-MRI was strongly correlated with histologic estimates of hypoxia. This approach was then applied to address the effects of antivascular agents on tumor oxygenation, which is a research question that is still under debate. The technique was used to monitor longitudinal pO2 changes in response to an antibody to vascular endothelial growth factor (B20.4.1.1) and a selective dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor (GDC-0980). GDC-0980 reduced viable tumor pO2 during a 3-day treatment period, and a significant reduction was also produced ...Continue Reading

Citations

Oct 3, 2018·The British Journal of Radiology·James P B O'ConnorJohn C Waterton
Feb 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Virginia SpanoudakiDaniel G Anderson
Dec 1, 2017·Frontiers in Cellular and Infection Microbiology·Ran ChengTao Hu
Feb 13, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Monique R BernsenMarion de Jong
Oct 17, 2020·International Journal of Nanomedicine·Lina WuXilin Sun

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