Mapping influenza transmission in the ferret model to transmission in humans

ELife
Michael G BuhnerkempeJames O Lloyd-Smith

Abstract

The controversy surrounding 'gain-of-function' experiments on high-consequence avian influenza viruses has highlighted the role of ferret transmission experiments in studying the transmission potential of novel influenza strains. However, the mapping between influenza transmission in ferrets and in humans is unsubstantiated. We address this gap by compiling and analyzing 240 estimates of influenza transmission in ferrets and humans. We demonstrate that estimates of ferret secondary attack rate (SAR) explain 66% of the variation in human SAR estimates at the subtype level. Further analysis shows that ferret transmission experiments have potential to identify influenza viruses of concern for epidemic spread in humans, though small sample sizes and biological uncertainties prevent definitive classification of human transmissibility. Thus, ferret transmission experiments provide valid predictions of pandemic potential of novel influenza strains, though results should continue to be corroborated by targeted virological and epidemiological research.

References

May 1, 1982·American Journal of Epidemiology·I M LonginiJ P Fox
Apr 9, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul K S Chan
Oct 1, 2004·Lab Animal·John A Maher, Joanne DeStefano
Oct 13, 2004·The Journal of Infectious Diseases·M Louise HerlocherArnold S Monto
Mar 24, 2006·Nature·Kyoko ShinyaYoshihiro Kawaoka
Aug 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Taronna R MainesJacqueline M Katz
May 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jessica A BelserTerrence M Tumpey
Feb 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Neal Van HoevenTerrence M Tumpey
Sep 25, 2010·PLoS Pathogens·Maki KisoYoshihiro Kawaoka
Jan 7, 2011·The Journal of Infectious Diseases·Matthew J MemoliJeffery K Taubenberger
Jan 1, 2010·Viruses·Nicole M Bouvier, Anice C Lowen
Aug 6, 2011·Antiviral Therapy·Marie-Eve HamelinGuy Boivin
Jan 13, 2012·PloS One·Tjandra Y AditamaI Nyoman Kandun
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Peter Palese, Taia T Wang
Feb 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Melissa B PearceTerrence M Tumpey
Jun 23, 2012·Nature·David M MorensJeffery K Taubenberger
Jun 23, 2012·Science·Sander HerfstRon A M Fouchier
Oct 9, 2012·Nature Medicine·Seema S Lakdawala, Kanta Subbarao
Apr 13, 2013·The New England Journal of Medicine·Rongbao GaoYuelong Shu
Apr 26, 2013·The New England Journal of Medicine·Qun LiZijian Feng
Jul 12, 2013·Nature·Tokiko WatanabeYoshihiro Kawaoka
Aug 9, 2013·Nature·Ron A M FouchierRobert G Webster
Sep 6, 2013·Nature·Marc Lipsitch
Apr 4, 2014·Journal of Virology·Troy C SuttonDaniel R Perez
May 23, 2014·PLoS Medicine·Marc Lipsitch, Alison P Galvani
Jun 3, 2014·BMC Infectious Diseases·Zhenyu GongEnfu Chen
Jun 13, 2014·Cell Host & Microbe·Tokiko WatanabeYoshihiro Kawaoka
Oct 17, 2014·ELife·Colin A RussellJesse D Bloom

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Citations

Feb 13, 2016·Frontiers in Microbiology·Ding Y Oh, Aeron C Hurt
May 25, 2016·Annual Review of Genomics and Human Genetics·Tommy T-Y LamEdward C Holmes
Nov 12, 2016·ELife·Marc LipsitchColin A Russell
Mar 3, 2017·Scientific Reports·Edward M HillThomas House
Feb 22, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jie ZhouHui-Ling Yen
Jul 15, 2016·Microbiology and Molecular Biology Reviews : MMBR·Jessica A BelserTaronna R Maines
Oct 17, 2018·PLoS Genetics·Casper K LumbyChristopher J R Illingworth
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Jessica A BelserTaronna R Maines
Mar 2, 2019·Tropical Medicine and Infectious Disease·Joanna A Pulit-PenalozaTaronna R Maines
Oct 5, 2019·Influenza and Other Respiratory Viruses·Julius WongStephen J Kent
Feb 5, 2019·The Journal of Infectious Diseases·Gabriele Neumann, Yoshihiro Kawaoka
Apr 9, 2019·Journal of the Royal Society, Interface·Linsey C MarrSeema S Lakdawala
Feb 9, 2017·PLoS Pathogens·Ashley Sobel LeonardChristopher J R Illingworth
Sep 3, 2021·Scientific Reports·Sima AsadiWilliam D Ristenpart

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