Mapping inter-regional connectivity of the entire cortex to characterize major depressive disorder: a whole-brain diffusion tensor imaging tractography study

Neuroreport
Mayuresh S KorgaonkarStuart M Grieve

Abstract

Diffusion tensor imaging (DTI) can be used to study the organization of brain white matter noninvasively. The aim of this study was to present a proof of concept for integrating DTI with high-resolution anatomical (T1) images to map and assess inter-regional connectivity across the entire cortex in a cohort of healthy participants and compared with patients with major depressive disorder. We used MRI data of 23 patients and 23 matched controls, assessed as part of baseline testing in the International Study to Predict Optimized Treatment in Depression (iSPOT-D). Freesurfer was used to analyze the T1 images to automatically label 35 gyral-based areas for each hemisphere. DTI tractography was performed to parcellate intercortical tracts using each of these areas in seed-target combinations. We quantified fractional anisotropy, number-of-fiber connections, and fiber path length for each DTI connection, with the goal of identifying the best measure or combination of measures to characterize major depression. The best classification accuracy for the individual measures was achieved using the number-of-fibers data, whereas the combination model provided a slight improvement. The most discriminant features between the two groups were ...Continue Reading

References

Dec 19, 2002·NMR in Biomedicine·K O Lim, J A Helpern
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Nov 25, 2005·Cerebral Cortex·M F S RushworthH Johansen-Berg
Dec 19, 2006·Journal of Affective Disorders·J Douglas SteeleIan Reid
Apr 4, 2007·The American Journal of Psychiatry·Cynthia H Y FuEdward T Bullmore
May 1, 2007·NeuroImage·Y Iturria-MedinaJ M Sánchez-Bornot
Jan 19, 2008·Brain : a Journal of Neurology·Stefan KlöppelRichard S J Frackowiak
May 13, 2008·Brain : a Journal of Neurology·Holly BridgeAlan Cowey
Jul 4, 2008·PLoS Biology·Patric HagmannOlaf Sporns
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Feb 25, 2009·Journal of Affective Disorders·Valentina LorenzettiMurat Yücel
Jun 23, 2009·Journal of Affective Disorders·Tsutomu TakahashiNicholas B Allen

❮ Previous
Next ❯

Citations

Nov 26, 2013·NeuroImage. Clinical·Stuart M GrieveLeanne M Williams
Aug 6, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Zhiliang LongHuafu Chen
Jun 28, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Mayuresh S KorgaonkarStuart M Grieve
Oct 20, 2015·Depression and Anxiety·Doreen M OlvetRamin V Parsey
Jun 17, 2015·Neuroinformatics·Edward H HerskovitsRong Chen
Dec 3, 2014·Biological Psychiatry·Qiyong Gong, Yong He
Apr 3, 2014·Biological Psychiatry·Mayuresh S KorgaonkarStuart M Grieve
Aug 4, 2015·Journal of Affective Disorders·Kee F ChiStuart M Grieve
Sep 29, 2015·BioMed Research International·Trong-Kha TruongNan-Kuei Chen
Apr 30, 2015·The Neuroradiology Journal·Rong Chen, Edward Herskovits
Jun 3, 2014·Behavioural Brain Research·Jerome J MallerPaul B Fitzgerald
Mar 31, 2017·Journal of Geriatric Psychiatry and Neurology·Filippo CieriMassimo di Giannantonio
Mar 24, 2018·BioMed Research International·Filippo Cieri, Roberto Esposito
Dec 18, 2020·Frontiers in Psychiatry·Yiming FanLingjiang Li
Aug 11, 2021·Journal of Affective Disorders·Feng FangYingchun Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.