journal cover

Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C

Nature Genetics

May 6, 2015

Borbala MifsudCameron Osborne

Abstract

Transcriptional control in large genomes often requires looping interactions between distal DNA elements, such as enhancers and target promoters. Current chromosome conformation capture techniques do not offer sufficiently high resolution to interrogate these regulatory interactions on ...read more

Mentioned in this Paper

Study
Transcriptional Regulation
Genome
Genes
Regulation of Biological Process
Transcription, Genetic
Promoter
Cell Communication
Genome Mapping
Human Cell Line
70
5
3
923
1
1
Paper Details
References
  • References35
  • Citations153
1234
  • References35
  • Citations153
12345...

Similar Papers Found In These Feeds

RNAi & Gene Silencing

RNA Interference (RNAi) pathway is involved in post-transcriptional gene silencing, transcriptional silencing and epigenetic silencing as well as its use as a tool for forward genetics and therapeutics. Discover the latest research here.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Enhancers in Development & Diseases (Keystone)

Enhancers are short regions of the DNA which can be bound by activator or repressor proteins to affect transcription of a particular gene. This feed covers the latest research on enhancer function in development and disease.

© 2020 Meta ULC. All rights reserved

Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C

Nature Genetics

May 6, 2015

Borbala MifsudCameron Osborne

PMID: 25938943

DOI: 10.1038/ng.3286

Abstract

Transcriptional control in large genomes often requires looping interactions between distal DNA elements, such as enhancers and target promoters. Current chromosome conformation capture techniques do not offer sufficiently high resolution to interrogate these regulatory interactions on ...read more

Mentioned in this Paper

Study
Transcriptional Regulation
Genome
Genes
Regulation of Biological Process
Transcription, Genetic
Promoter
Cell Communication
Genome Mapping
Human Cell Line
70
5
3
923
1
1

Similar Papers Found In These Feeds

RNAi & Gene Silencing

RNA Interference (RNAi) pathway is involved in post-transcriptional gene silencing, transcriptional silencing and epigenetic silencing as well as its use as a tool for forward genetics and therapeutics. Discover the latest research here.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Related Papers

Paper Details
References
  • References35
  • Citations153
1234
  • References35
  • Citations153
12345...
/papers/mapping-long-range-promoter-contacts-in-human/25938943