Mapping murine loci for physical dependence on ethanol

Psychopharmacology
Kari J BuckJohn C Crabbe

Abstract

Alcoholism is associated with withdrawal (physical dependence), tolerance, or a maladaptive pattern of alcohol (ethanol) use. The well-documented difference in susceptibility to withdrawal after chronic ethanol exposure between the C57BL/6J and DBA/2J mouse strains provides an excellent starting point for dissecting genetic influences involved in physical dependence on ethanol. A quantitative trait locus (QTL) identifies the genomic location of a gene (or genes) affecting a trait of interest. A genome-wide QTL mapping study was carried out to dissect the multifactorial nature of withdrawal after chronic ethanol exposure using 400 B6D2F2 mice. To induce physical dependence, we used a standard paradigm in which mice were exposed to ethanol vapor for 72 h. The mice were then tested hourly for handling-induced convulsions (HICs) for 10 h and at hours 24 and 25. Ethanol withdrawal severity was first computed as the area under the 25-h HIC curve. Separate regression residuals were then calculated that corrected for individual differences in blood ethanol concentration at the time of withdrawal and baseline HIC severity (i.e. before ethanol exposure). Statistical mapping yielded significant evidence ( P<0.00005) for QTLs on chromosome...Continue Reading

Citations

Feb 6, 2004·Pharmacology & Therapeutics·Deborah A FinnJohn C Crabbe
Jul 1, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Ellen Heber-KatzElizabeth P Blankenhorn
Jun 5, 2002·Alcoholism, Clinical and Experimental Research·Judith E GriselJohn C Crabbe
Dec 28, 2002·Genome Génome / Conseil National De Recherches Canada·Belén RománZlatko Satovic
Feb 22, 2012·Genome Biology·Tatiana V MorozovaRobert R H Anholt
Sep 26, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gang ChenKari J Buck
Feb 19, 2013·Alcohol·Walter D McCulleyAlan M Rosenwasser
Dec 15, 2004·Alcoholism, Clinical and Experimental Research·Robert HitzemannJohn Crabbe
May 18, 2005·Alcoholism, Clinical and Experimental Research·Christoph FehrTamara J Phillips
Sep 14, 2007·Alcoholism, Clinical and Experimental Research·Julia A Chester, Gustavo D Barrenha
May 16, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Claire R QuilterNabeel A Affara
Mar 6, 2010·Alcoholism, Clinical and Experimental Research·Howard J EdenbergTatiana Foroud
Jul 15, 2004·Pharmacology, Biochemistry, and Behavior·Deborah A FinnJohn C Crabbe
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Jan 13, 2015·Alcoholism, Clinical and Experimental Research·Pamela MettenRobert J Hitzemann
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May 19, 2005·Psychiatric Genetics·Kirk C Wilhelmsen, Cindy Ehlers
Nov 12, 2003·The Journal of Pharmacology and Experimental Therapeutics·Christopher M ButtAllan C Collins

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