PMID: 11911594Mar 26, 2002Paper

Mapping neutralizing and non-neutralizing epitopes on the capsid protein of feline calicivirus

Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health
K GeisslerU Truyen

Abstract

Neutralizing epitopes on feline calicivirus (FCV) capsid protein were mapped using chimeric capsid proteins recombinant between two FCV isolates that do not show any cross-neutralization. The three chimeric proteins examined were expressed in murine L929 cells employing an MVA/T7 vaccinia virus expression system and inoculated into major histocompatibility complex haplotype-matched C3/HN mice. Based on the neutralizing antibody titre the neutralizing epitope(s) could be mapped to the 5' hypervariable region of the E region or potentially to the C region. The epitopes of some non-neutralizing antibodies were mapped with the same chimeric proteins to the regions B or D and F of the FCV capsid protein.

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Citations

Jan 17, 2007·Veterinary Research Communications·K OheA Taneno
Sep 28, 2007·Veterinary Research Communications·Kyoko OheMotonobu Hara
Jun 2, 2009·Journal of Feline Medicine and Surgery·Alan D RadfordMarian C Horzinek
Jul 25, 2003·Journal of Feline Medicine and Surgery·E M Schorr-EvansN C Pedersen
May 28, 2005·Journal of Virology·Tracy Dewese ParkerMary K Estes
Feb 26, 2013·Research in Veterinary Science·Mara BattilaniAlessandra Scagliarini
May 27, 2008·The Veterinary Clinics of North America. Small Animal Practice·David Scott McVey, Melissa Kennedy
May 27, 2014·The Veterinary Journal·J M Monné RodriguezA Kipar
Nov 30, 2005·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Mohamed Abd-EldaimMelissa Kennedy
Feb 16, 2018·Journal of Clinical Microbiology·Randall W RenshawEdward J Dubovi
Mar 20, 2018·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Joylson de Jesus PereiraTatiana Xavier de Castro
Feb 14, 2007·Veterinary Research·Alan D RadfordRosalind M Gaskell

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