PMID: 7538228Jan 1, 1995Paper

Mapping of arthritogenic/autoimmune epitopes of cartilage aggrecans in proteoglycan-induced arthritis

Scandinavian Journal of Rheumatology. Supplement
T T GlantK Mikecz

Abstract

Immunization of BALB/c mice with chondroitin sulfate-depleted proteoglycan (aggrecan) of fetal human cartilage produces progressive polyarthritis and ankylosing spondylitis. The development of the disease in genetically susceptible BALB/c mice is dependent upon the expression of both cell-mediated and humoral immune responses against the host mouse cartilage proteoglycan (PG). Although cartilage PGs from various species have many biochemical and immunological similarities, only a select group of PGs from fetal and newborn human, fetal pig and canine articular cartilages, human osteophytes and human chondrosarcomas are able to induce arthritis in BALB/c mice. Arthritis develops only in mice that also develop autoantibodies to self-cartilage PGs, although autoantibodies occasionally are present in non-arthritic animals as well. The protease-sensitive auto/arthritogenic epitope(s) is located in, or close to, the chondroitin sulfate (CS) attachment region of the PG molecule. The primary structure of the core protein is responsible for the autoimmune/arthritogenic effect of this select group of PGs, whereas the core protein epitopes are masked by glycosaminoglycan (GAG)-side chains. The CS side chains seem to inhibit antigen recogni...Continue Reading

References

Jan 1, 1979·Scandinavian Journal of Immunology·T GlantM Nagy
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Dec 1, 1979·Archives of Biochemistry and Biophysics·M B SweetJ Marsh
Feb 1, 1987·Arthritis and Rheumatism·T T GlantA R Poole
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·W van EdenI R Cohen
Jun 1, 1984·Cellular Immunology·E E Golds, A R Poole
Mar 1, 1993·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J M WilliamsT T Glant
Jan 1, 1980·Scandinavian Journal of Immunology·T GlantT Szücs

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