Mapping of B-cell epitopes recognized by antibodies to histones in subsets of juvenile chronic arthritis

Clinical Immunology and Immunopathology
C StemmerS Muller

Abstract

The sera of 138 patients with juvenile chronic arthritis (JCA) were tested in ELISA with the five individual histones, 34 histone peptides covering the full length of the four core histones, and two peptides corresponding to the N- and C-terminal domains of H1. The occurrence of IgG antibodies was examined regarding the different subsets of JCA (pauciarticular, polyarticular, and systemic onset) and regarding clinical features (chronic anterior uveitis, CAU) and other serological features (antinuclear antibodies, ANA). Seventy-two percent of the 138 sera reacted with at least 1 histone peptide. The peptides 204-218 of H1, 1-25 of H2B, and 111-130 of H3 were recognized by 22-28% of JCA sera, and 42% of JCA sera reacted with one or both peptides 1-25 of H2B and 111-130 of H3. The frequency of occurrence of anti-histone antibodies (AHA) regarding the type of histone fraction (H1, H2A, H2B, H3 and H4) or the regions of histones was not significantly different in the three subsets of JCA. No obvious association was found between IgG antibodies to histone peptides and uveitis. In the subset of pauciarticular JCA, 13/31 patients (41.9%) with CAU against 14/41 patients (34.1%) without CAU possessed IgG antibodies reacting with peptides...Continue Reading

Citations

Jun 26, 1998·Journal of Gastroenterology and Hepatology·M ChenM Nishioka
Dec 8, 1998·Australian and New Zealand Journal of Ophthalmology·J R Smith, D J Coster
Jan 1, 2010·Arthritis·V WiegeringH Morbach
May 6, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Li ZhengLouis Nadjo
Aug 19, 2014·Survey of Ophthalmology·Viera Kalinina AyusoJoke H de Boer
Apr 6, 2002·Ocular Immunology and Inflammation·V F TrevisaniL E Andrade
Feb 26, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stéphanie LacotteSylviane Muller

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