PMID: 8597632Nov 1, 1995Paper

Mapping of body weight loci on mouse chromosome X

Mammalian Genome : Official Journal of the International Mammalian Genome Society
T A DraganiM A Pierotti

Abstract

Inheritance of overweight in humans appears to be under polygenic control. Study on the mouse model may help to determine candidate regions in human genome for the search of overweight genes. Inbred mouse strains showed wide variation in body weight and can provide an experimental model for the study of inheritance of overweight. By genetic linkage analysis, we report the mapping of two loci, named Bw1 and Bw2 (body weight 1 and 2), on Chromosome (Chr) X that strongly affect adult body weight in two interspecific testcross male populations (HSB) and ASB) of mice. In addition, another locus, named Bw3, is also mapped on Chr X in ASB populations. These loci account for up to 24% of the phenotypic variation in both populations. Considering the conserved synteny between mouse and humans Chr X, these results provide candidate regions on Chr X that can be tested for linkage with overweight in humans.

References

Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J M FriedmanN Bahary
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E S Lander, P Green
Dec 1, 1985·Annals of Internal Medicine·J G Kral
Dec 1, 1985·Annals of Internal Medicine·G A Bray
Oct 1, 1994·The Journal of Clinical Investigation·D B WestG E Truett
Sep 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·D B WestR A Price
Apr 1, 1994·Genetics·Z B Zeng
Aug 1, 1993·The Journal of Clinical Investigation·C H WardenA J Lusis
Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A C CollinsB W Kirkpatrick

❮ Previous
Next ❯

Citations

Jul 15, 2003·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Danielle R ReedAlexander A Bachmanov
Sep 25, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Rosemary W ElliottJoanne Pazik
Jul 31, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Marisela R RodriguezMichael G Brown
Sep 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·B YorkD B West
Apr 8, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·P KovácsI Klöting
Jul 8, 1999·Journal of Internal Medicine·S M Echwald
Oct 6, 2000·American Journal of Respiratory Cell and Molecular Biology·S L EwartM Wills-Karp
Jun 17, 1998·The Journal of Clinical Investigation·M MehrabianA J Lusis
Apr 19, 2005·Obesity Research·Louis PérusseClaude Bouchard
Mar 27, 2004·Obesity Research·Eric E SnyderClaude Bouchard
Mar 14, 2003·Obesity Research·Yvon C ChagnonClaude Bouchard
Jun 3, 2006·Obesity·Tuomo RankinenClaude Bouchard
Jan 1, 1997·Obesity Research·L PérusseC Bouchard
Apr 4, 1998·Obesity Research·Y C ChagnonC Bouchard
Feb 19, 1999·Obesity Research·L PérusseC Bouchard
Mar 11, 2000·Obesity Research·Y C ChagnonC Bouchard
Mar 12, 2002·Obesity Research·Tuomo RankinenClaude Bouchard
Apr 24, 2001·Obesity Research·L PérusseC Bouchard
Nov 28, 2000·Japanese Journal of Cancer Research : Gann·T A DraganiI Nakashima
Aug 23, 2001·Experimental Animals·R V AnunciadoT Namikawa
Apr 15, 2000·Nature·G S BarshS O'Rahilly
Oct 25, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S WuschkeH Al-Hasani
Jul 23, 2015·Genetics·Melissa M GrayBret A Payseur
Jul 16, 2002·Physiological Genomics·Larry J LeamyJames M Cheverud
May 1, 1997·The Journal of Nutrition·G A Bray
Jan 1, 2013·G3 : Genes - Genomes - Genetics·Chevonne D EversleyDavid W Threadgill
Sep 1, 1997·The Journal of Nutrition·J S Fisler, C H Warden
May 8, 1998·Methods : a Companion to Methods in Enzymology·P Avner
Nov 1, 1996·Trends in Genetics : TIG·Y C Chagnon, C Bouchard
Dec 1, 1996·Endocrinology and Metabolism Clinics of North America·D B West

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.