Sep 1, 1989

Mapping of cat albumin using monoclonal antibodies: identification of determinants common to cat and dog

Clinical and Experimental Immunology
Y BoutinW Mourad

Abstract

Cat and dog albumins from commercial extracts were used to produce monoclonal antibodies (MoAb). Anti-cat albumin MoAb recognized both cat and dog albumin equally, as did anti-dog albumin MoAb; this confirms cross-reactivity between cat and dog. The MoAb were separated into two groups according to their epitopic specificity; they recognized two overlapping epitopes of cat albumin. Furthermore, by competitive inhibition of radio-allergosorbent test (RAST), it was shown that one MoAb group inhibited significantly the binding of human IgE antibodies (from a pool of 13 patients allergic to both cats and dogs) to insolubilized cat or dog extracts. These observations suggest that murine anti-cat or anti-dog MoAb and human IgE antibodies recognize identical or closely related determinants on cat and dog albumin.

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Mentioned in this Paper

Monoclonal Antibodies
Monoclonal antibodies, antineoplastic
Alb
Murine
Antigenic Specificity
ALB
Radioallergosorbent Test
Cross Reactions
MUROMONAB-CD3, Parenteral,5 MG Administered
Mus

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