PMID: 8971043Dec 1, 1996Paper

Mapping of independent V3 envelope determinants of human immunodeficiency virus type 1 macrophage tropism and syncytium formation in lymphocytes

Journal of Virology
B ChesebroS Perryman

Abstract

The V3 region of the human immunodeficiency virus type 1 (HIV-1) envelope protein is known to have a major influence on macrophage tropism as well as the ability to cause syncytium formation or fusion in CD4-positive lymphocyte cultures. Using infectious molecular HIV-1 clones, a series of mutant clones was created which allowed detailed mapping of V3 amino acid positions involved in these properties. In these experiments the non-syncytium-inducing phenotype in T cells did not always correlate with macrophage tropism. Macrophage tropism appeared to depend on the presence of certain combinations of amino acids at five specific positions within and just outside of the V3 loop itself, whereas syncytium formation in lymphocytes was influenced by substitution of particular residues at two to four positions within V3. In most cases, different V3 amino acid positions were found to independently influence macrophage tropism and syncytium formation in T cells and position 13 was the only V3 location which appeared to simultaneously influence both macrophage tropism and syncytium formation in lymphocytes.

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T ShiodaC Cheng-Mayer
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·T McNearneyL Ratner
Apr 1, 1992·Journal of Virology·P WesterveltL Ratner
Aug 1, 1981·The Journal of Experimental Medicine·M W CloydW P Rowe
Dec 1, 1994·AIDS Research and Human Retroviruses·E G ShpaerJ I Mullins
Nov 1, 1994·The Journal of Clinical Investigation·R A FouchierH Schuitemaker
Jun 4, 1993·Science·M GroeninkH Schuitemaker

❮ Previous
Next ❯

Citations

Jan 28, 2006·AIDS Research and Human Retroviruses·Kelly M CheneyPeng Li
Oct 13, 2005·Journal of Biomolecular Structure & Dynamics·A M Andrianov
Apr 28, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Frank A J KoningsPhillipe N Nyambi
Dec 10, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stéphanie RaymondJacques Izopet
Jul 16, 2016·AIDS Research and Human Retroviruses·Thaysse Cristina Neiva Ferreira LeiteMonick Lindenmeyer Guimarães
Jan 11, 2000·AIDS Research and Human Retroviruses·J SuA Vahlne
Dec 5, 2000·Journal of Acquired Immune Deficiency Syndromes : JAIDS·R MachucaC Nielsen
Jun 25, 2002·AIDS Research and Human Retroviruses·Caterina SerraAntonina Dolei
Jun 29, 2004·Journal of Virology·Cristina PastoreDonald E Mosier
Nov 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Oliver HartleyRobin Offord
Feb 15, 2001·AIDS Research and Human Retroviruses·Y J ZhangJ P Moore
May 20, 1999·Molecular Membrane Biology·T L Hoffman, R W Doms
Jun 1, 2006·Brain : a Journal of Neurology·Satish K PillaiJoseph K Wong
Apr 18, 2002·AIDS Research and Human Retroviruses·M A ArroyoL M Meléndez-Guerrero
Sep 5, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Denis M TebitHans-Georg Krausslich
Sep 26, 2008·Journal of Virology·Mia CoetzerDonald E Mosier
Jul 23, 2013·The Journal of Antimicrobial Chemotherapy·Stéphanie RaymondJacques Izopet
Sep 10, 2003·Journal of Leukocyte Biology·Maureen M GoodenowJohn W Sleasman
Feb 1, 2003·FEBS Letters·Alexander M ColeOtto O Yang
Nov 28, 2007·PLoS Computational Biology·Art F Y PoonSimon D W Frost
Nov 3, 2009·Yonsei Medical Journal·Fei ZhaoWen-Jie Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.