PMID: 2111277Apr 1, 1990Paper

Mapping of mouse carbonic anhydrase-3, Car-3: another locus in the homologous region of mouse chromosome 3 and human chromosome 8

Genomics
C BeecheyY Edwards

Abstract

At least six separate genes determining tissue- and organelle-specific isoforms of carbonic anhydrase are known. We have determined the chromosome location of one of these genes, carbonic anhydrase-3 (Car-3), in the mouse and carried out a linkage analysis of Car-1, Car-2, and Car-3. Car-3 has been assigned to band 3A2 by in situ hybridization. We identified a PstI restriction fragment length polymorphism between Mus spretus and Mus mus domesticus and, by using an interspecific backcross, showed that Car-3 is 2.4 +/- 1.7% SE from both Car-1 and Car-2, calculating genetic distance as percentage recombination. No recombinants were found between Car-1 and Car-2 in 100 backcross offspring, and when these data are combined with earlier results, these two loci are estimated to be 1.2 cM from each other at the 95% confidence interval. The three homologous carbonic anhydrase loci in man had earlier been assigned to 8q22, and the finding of linkage of Car-3 to Car-1 and Car-2 in the mouse adds another locus to the conserved segments on mouse chromosome 3 and human chromosome 8.

References

Jan 1, 1979·Cytogenetics and Cell Genetics·A G SearleL L Washburn
Feb 1, 1989·Biochemical Genetics·S Tweedie, Y Edwards
May 1, 1989·Annals of Human Genetics·A G SearleV J Buckle
Jan 1, 1987·Cytogenetics and Cell Genetics·H NakaiT B Shows
May 1, 1986·Annals of Human Genetics·Y H EdwardsP H Butterworth
Jan 1, 1973·Chromosoma·M N Nesbitt, U Francke
Nov 15, 1972·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·N D Carter
Oct 1, 1984·Biochemical Genetics·J B Whitney

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Citations

Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L T KnappS A Camper
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M H MeislerM F Seldin
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M H Meisler, M F Seldin
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H NadeauT H Roderick
Jan 1, 1992·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H NadeauT H Roderick
Jun 1, 1992·American Journal of Medical Genetics·L A BruetonH M Kingston

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