Mapping of NRAGE domains reveals clues to cell viability in BMP signaling.

Apoptosis : an International Journal on Programmed Cell Death
Jennifer A RochiraJoseph M Verdi

Abstract

Bone morphogenetic signaling (BMP) is a key pathway during neurogenesis and depends on many downstream intermediators to carry out its signaling. One such signaling pathway utilizes neurotrophin receptor-interacting MAGE protein (NRAGE), a member of the melanoma-associated antigen (MAGE) family, to upregulate p38 mitogen activated protein kinase (p38(MAPK)) in response to cellular stress and activate caspases which are critical in leading cells to death. NRAGE consists of two conserved MAGE homology domains separated by a unique hexapeptide repeat domain. Although we have previously implicated NRAGE in inducing apoptosis in neural progenitors and P19 cells, a model system for neural progenitors, its domains have yet to be explored in determining which one may be responsible for setting up the signaling for apoptosis. Here, we overexpressed a series of deletion mutations in P19 cells to show that only those with at least half of the repeat domain, activated p38(MAPK) and underwent apoptosis offering intriguing incite into NRAGE's contribution in BMP apoptotic signaling.

References

Jan 1, 1994·Annual Review of Immunology·T BoonA Van Pel
Jul 17, 1997·Nature·Q L DeverauxJ C Reed
Nov 21, 2000·The Journal of Biological Chemistry·Y MasudaK Watanabe
Mar 14, 2002·Journal of Neuroscience Research·Philip A Barker, Amir Salehi
Jun 29, 2004·World Journal of Gastroenterology : WJG·Jiang Xiao, Hong-Song Chen
Aug 19, 2005·Molecular and Cellular Biology·Stephen E KendallJoseph M Verdi
Dec 5, 2006·Cancer Letters·Chao-shun ChuChuan-Jun Wen
Jan 3, 2008·Cancer Cell·Ichiro NakanoHarley I Kornblum
Mar 10, 2009·Mechanisms of Development·George N NikopoulosJoseph M Verdi

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Citations

Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ge ZhangXiaoying Xue
Jul 14, 2010·Applied Microbiology and Biotechnology·Torben HoefelDirk Weuster-Botz
Sep 15, 2020·The Journal of Biological Chemistry·Rebecca R Florke GeePatrick Ryan Potts

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