Mapping of the gene encoding the integrin-linked kinase, ILK, to human chromosome 11p15.5-p15.4

Genomics
Gregory E HanniganJ A Squire

Abstract

We have recently reported the identification and cloning of the gene encoding p59ILK, a novel protein ser/thr kinase that is found in physiologic complexes with beta integrin subunits. ILK is a potential protoonocogene that appears to function in mediating signal transduction by beta 1 family integrins. Fluorescence in situ hybridization analysis of metaphase and decondensed free chromatin fibers localized ILK to 11p15.5-p15.4. This position was also confirmed by relational mapping using well-characterized translocations with breakpoints in chromosome band 11p15. Our results indicate that ILK maps between HBBC and CALC loci, in the 11p15.5-p15.4 band interval. This location may be important in evaluating the potential role of p59ILK in tumorigenesis since it has been shown that this region is associated with both genomic imprinting and loss of heterozygosity in certain types of tumor.

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Citations

Nov 2, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Pei Kang, Kathy K H Svoboda
Jan 5, 2005·Nature Reviews. Cancer·Gregory HanniganShoukat Dedhar
Apr 20, 2007·Human Pathology·Mayumi OkamuraYoshiaki Ishigatsubo
Feb 9, 2007·Cancer Letters·Jane Bayani, Jeremy A Squire
Aug 10, 2004·International Journal of Cancer. Journal International Du Cancer·Ping ChenPratima Karnik
Nov 7, 2006·Biochimica Et Biophysica Acta·Stephanie HehlgansNils Cordes
Nov 30, 2010·Biochimica Et Biophysica Acta·Alberto Fernández-Medarde, Eugenio Santos
Mar 29, 2002·Environmental and Molecular Mutagenesis·Jose RussoIrma H Russo
Jul 26, 2005·Journal of Dental Research·P Kang, K K H Svoboda
Jul 17, 1999·Trends in Cell Biology·S DedharG Hannigan
Apr 12, 2001·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J RussoI H Russo
Mar 19, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Jose RussoIrma H Russo
Nov 25, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Jose RussoIrma H Russo

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