Mapping of the genes encoding human inducible and endothelial nitric oxide synthase (NOS2 and NOS3) to the pericentric region of chromosome 17 and to chromosome 7, respectively

Genomics
W XuP Emson

Abstract

Nitric oxide (NO) is an important molecular messenger regulating the functions of a wide variety of cells and tissues. NO is synthesized from L-arginine by a variety of isoforms of the enzyme nitric oxide synthase (NOS). We have used Southern blotting analysis on DNAs obtained from a panel of human-rodent hybrid cell lines to map the gene encoding the inducible NOS (NOS2) to chromosome 17cen-17q11 and the gene encoding the endothelial form of NOS (NOS3) to chromosome 7. Fluorescence in situ hybridization using a NOS2 probe gave several signals in the 17p11-q11 pericentromeric region.

Citations

Feb 17, 2001·Heart·P Vallance, N Chan
Feb 1, 1996·Clinical and Experimental Hypertension : CHE·S Nadaud, F Soubrier
Feb 18, 2003·Fundamental & Clinical Pharmacology·Patrick Vallance
May 26, 2005·Seminars in Cancer Biology·Matthias LechnerJosef Rieder
Oct 13, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ambros HuberLukas Hefler
Feb 7, 1998·Cephalalgia : an International Journal of Headache·L L Thomsen
Mar 30, 2013·International Journal of Molecular Sciences·Frank SuhrWilhelm Bloch
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·J N WilcoxP A Marsden
Jun 20, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Hyo-Won KimHee-Jeong Yoo
Dec 31, 2008·International Journal of Cancer. Journal International Du Cancer·Chih-Ching YehReiping Tang
Mar 16, 2006·Breast Cancer Research and Treatment·Lukas A HeflerRobert Zeillinger
Jun 28, 2011·Molecular Biology Reports·Soykan ArıkanIlhan Yaylım-Eraltan
Feb 13, 2018·Oncology Letters·Wenhua JiangXiaodong Li
Apr 10, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Shafiul HaqueMohtashim Lohani
Aug 1, 1997·Nitric Oxide : Biology and Chemistry·C S ParkG Krishna
Oct 26, 1995·Biochemical Pharmacology·U FörstermannH Kleinert
Aug 14, 1996·Biochimica Et Biophysica Acta·K GnanapandithenP A Marsden

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.