Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21

Genomics
H M AplinM J Dixon

Abstract

Dentinogenesis imperfecta type II (DGI1) is an autosomal dominant disorder of dentin formation, which has been mapped to human chromosome 4q12-q21. The region most likely to contain the DGI1 locus is a 3.2-cM region surrounding the osteopontin (SPP1) locus. Recently, a novel dentin-specific acidic phosphoprotein (dmp1) has been cloned in the rat and mapped to mouse chromosome 5q21. In the current investigation, we have isolated a cosmid containing the human DMP1 gene. The isolation of a short tandem repeat polymorphism at this locus has allowed us to map the DMP1 locus to human chromosome 4q21 and demonstrate that it is tightly linked to DGI1 in two families (Zmax = 11.01, theta = 0.001). The creation of a yeast artificial chromosome contig around SPP1 has further allowed us to demonstrate that DMP1 is located within 150 kb of the bone sialoprotein and 490 kb of the SPP1 loci, respectively. DMP1 is therefore a strong candidate for the DGI1 locus.

Citations

Oct 17, 1998·Australian Dental Journal·G C TownsendP M Bartold
May 12, 2001·European Journal of Oral Sciences·C QinW T Butler
Sep 4, 2003·Connective Tissue Research·Mary MacDougall
Feb 8, 2006·European Journal of Oral Sciences·Jung-Wook KimJames P Simmer
Mar 18, 2016·Brazilian Oral Research·Cigdem AtalayinGulperi Oktem
Jun 23, 2005·Archives of Oral Biology·N Laila HuqEric C Reynolds
Nov 4, 2000·Pediatric Clinics of North America·J T Wright
Mar 1, 1997·Journal of Dental Research·K L HirstM J Dixon
Jun 17, 1999·Journal of Dental Research·M MacDougallR J Leach
Feb 22, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·T C HartJ T Wright
Apr 12, 2000·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·B GanssJ Sodek
Oct 9, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jian Q FenMary MacDougall
May 8, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jelica Gluhak-HeinrichDubravko Pavlin
Jan 8, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R N D'SouzaM MacDougall
Apr 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M MacDougallJ Chen
Sep 7, 2006·American Journal of Medical Genetics. Part a·Mary MacDougallAna Carolina Acevedo
May 4, 2012·International Journal of Molecular Medicine·Jing YueFuchun Fang
Jan 21, 2016·Molecular Genetics & Genomic Medicine·Jie YangJan C-C Hu
Jun 27, 1998·Oral Diseases·K Kurisu, M J Tabata
Oct 24, 2000·The Journal of Biological Chemistry·C QinW T Butler
May 9, 2001·American Journal of Medical Genetics·D L DuffyN G Martin

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