Mapping of the human gene for inducible heme oxygenase to chromosome 22q12

The Tohoku Journal of Experimental Medicine
A KuwanoShigeki Shibahara

Abstract

Heme oxygenase is an essential enzyme in heme catabolism that cleaves heme to form biliverdin, releasing carbon monoxide and iron. There are two isozymes of heme oxygenase: heme oxygenase 1 (HO-1) and heme oxygenase 2, each of which is encoded by a separate gene. It is noteworthy that HO-1 is inducible by various environmental factors, while heme oxygenase 2 is not. Here we have localized the human HO-1 gene to chromosome 22 by polymerase chain reaction (PCR) analysis of human-hamster somatic cell hybrids. The precise region of the HO-1 locus was then determined by fluorescence in situ hybridization, revealing that the human HO-1 gene is localized to 22q12.

Citations

Sep 17, 2002·Antioxidants & Redox Signaling·Shigeki ShibaharaK Takahashi
Dec 10, 2002·Antioxidants & Redox Signaling·M Bauer, I Bauer
Sep 25, 2007·Antioxidants & Redox Signaling·Shigeki ShibaharaKazuhisa Takeda
Sep 6, 2007·The Tohoku Journal of Experimental Medicine·Kazumichi FuruyamaPatrick D Vargas
Oct 3, 2012·Progress in Neurobiology·Meijuan ZhangFeng Zhang
May 27, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Edward F ChangLinda J Noble-Haeusslein
Oct 29, 2003·The Tohoku Journal of Experimental Medicine·Shigeki Shibahara
Jan 28, 2021·International Journal of Molecular Sciences·Karolina Bukowska-StrakovaMaciej Siedlar

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