Mapping of the mouse atrial natriuretic factor gene. Evidence for tight linkage to the Fv-1 locus.

Hypertension
J J MullinsK W Gross

Abstract

The importance of atrial natriuretic factor (ANF) in the regulation of salt balance and blood pressure is now widely recognized, and it would be extremely informative for both physiologists and molecular biologists to have mutants available that exhibit abnormal expression of this peptide hormone. The most direct mutation would affect the structural gene itself by altering either its coding potential or its regulation. With this aim in mind, it is of considerable interest to accurately determine the chromosomal position of the ANF gene (Anf) in the mouse. This information would permit a comparison with known mutations and provide a means of screening for mutations at this locus. Using recombinant inbred mouse strains, we undertook the mapping of the mouse Anf gene and demonstrated linkage of the gene to the Friend virus susceptibility-1 (Fv-1) locus on chromosome 4. The mapping was performed using a restriction fragment length polymorphism extant between the two parental strains. No recombination event between Anf and the Fv-1 locus was evident in any of the 34 strains tested. The assignment of Anf to this region of chromosome 4 coincides with the reported position of the cribriform degeneration mutation, which includes in its ...Continue Reading

Citations

Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·K K LuedersE L Kuff
Jan 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J P StoyeS Best
Jan 11, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·R BlankB Mock
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J H Nadeau, M Kosowsky
Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D R BeierD J Sussman
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R W WisemanP Söderkvist

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