PMID: 7007825Jan 1, 1980Paper

Mapping of two transcription mutations (tlnI and tlnII) conferring thiolutin resistance, adjacent to dnaZ and rho in Escherichia coli

Molecular & General Genetics : MGG
N Sivasubramanian, R Jayaraman

Abstract

Two mutations in Escherichia coli conferring resistance to the transcription initiation inhibitor, thiolutin, have been mapped. One of these mutations (tln-I)( maps at 10.2 min on the genetic map and is cotransducible with dnaZ at a frequency of approximately 50%. The other mutation (tln-II) maps between metE and ilvD, probably close to rho, and is cotransducible with ilvD at a frequency of approximately 65%. The presence of both the mutations in the same cell confers resistance to thiolutin in minimal medium. Either one of them alone renders the cell 'conditionally auxotrophic' in the presence of the drug. The implications of these findings are discussed in relation to the mode of action of the thiolutin sensitive factors in transcription.

References

Jun 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·A DasS Adhya
Apr 23, 1976·Molecular & General Genetics : MGG·N Sivasubramanian, R Jayaraman
Jul 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·L LindahlM Nomura
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Citations

Jan 1, 1984·Molecular & General Genetics : MGG·S S Sastry, R Jayaraman
Jan 1, 1982·Molecular & General Genetics : MGG·A JoshiM Chakravorty
Oct 1, 1982·Antimicrobial Agents and Chemotherapy·A JoshiM Chakravorty
May 25, 2001·Antimicrobial Agents and Chemotherapy·A J O'Neill, I Chopra
Jul 23, 2004·Expert Opinion on Investigational Drugs·Alex J O'Neill, Ian Chopra
Sep 1, 1992·Journal of Bacteriology·C A ConlinC G Miller
Sep 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·M K Berlyn
Dec 1, 1993·Microbiological Reviews·M Riley

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