Mapping, phylogenetic and expression analysis of the RNase (RNase A) locus in cattle.

Journal of Molecular Evolution
Thomas T WheelerSandeep K Gupta

Abstract

The mammalian secreted ribonucleases (RNases) comprise a large family of structurally related proteins displaying considerable sequence variation, and have been used in evolutionary studies. RNase 1 (RNase A) has been assumed to play a role in digestion, while other members have been suggested to contribute to host defence. Using the recently assembled bovine genome sequence, we characterised the complete repertoire of genes present in the RNaseA family locus in cattle, and compared this with the equivalent locus in the human and mouse genomes. Several additions and corrections to the earlier analysis of the RNase locus in the mouse genome are presented. The bovine locus encodes 19 RNases, of which only six have unambiguous equivalent genes in the other two species. Chromosomal mapping and phylogenetic analysis indicate that a number of distinct gene duplication events have occurred in the cattle lineage since divergence from the human and mouse lineages. Substitution analysis suggests that some of these duplicated genes are under evolutionary pressure for purifying selection and may therefore be important to the physiology of cattle. Expression analysis revealed that individual RNases have a wide pattern of expression, includi...Continue Reading

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Citations

Jul 20, 2013·Genetics, Selection, Evolution : GSE·Lesley-Ann RavenBen J Hayes
Dec 18, 2013·Molecular Genetics and Genomics : MGG·Marko Premzl
Mar 13, 2014·Biomolecular NMR Assignments·Marco TonelliJohn L Markley
Nov 23, 2016·Developmental and Comparative Immunology·Sandeep K GuptaThomas T Wheeler
Jan 29, 2019·Integrative Zoology·Datian LangXiaoping Wang
Aug 1, 2014·The Journal of Biological Chemistry·Chelcie H EllerRonald T Raines

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