PMID: 6183241Jan 1, 1982Paper

Mapping, quantitative distribution and origin of substance p- and VIP-containing nerves in the uvea of guinea pig eye

Histochemistry
G TerenghiS R Bloom

Abstract

VIP- and substance P-like immunoreactivities were found in considerable concentrations (VIP: 17.3 +/- 4.8 pmol/g, mean +/- SEM; substance P:11.1 +/- 1.8 pmol/g) in the uveal portion of the guinea pig eye. Immunocytochemistry localised these two regulatory peptides to nerve fibres found principally in a plexus in the iris (substance P) and in an extensive network surrounding the blood vessels of the choroid (VIP). A remarkable anatomical demarcation of the two types of peptide-containing nerves was established by the staining of substance P-containing nerves, which stops at the level of the ciliary body. This uveal area is known to be involved in the ocular responses to nociceptive stimuli. At the ultrastructural level, immunoreactivity for both peptides was localised to distinct subpopulations of p-type nerves, distinguishable by the size of their large dense-cored vesicles. Those immunoreactive for VIP were significantly larger (p less than 0.0005) than those immunoreactive for substance P (95 +/- 7 nm and 82 +/- 9 nm respectively; mean +/- SD). Interruption of the trigeminal pathway produced a remarkable decrease of substance P immunoreactivity in the anterior portion of the uvea (9.1 +/- 1.5 pmol/g, mean +/- SEM, control; 5....Continue Reading

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Citations

Jul 15, 1987·Experientia·R A StoneA M Laties
Jul 15, 1987·Experientia·J Wharton, S Gulbenkian
Jan 1, 1990·Pharmacology & Therapeutics·M C MioneG Burnstock
Jan 1, 1991·Journal of the Autonomic Nervous System·C E HillF R Edwards
Nov 21, 1983·Neuroscience Letters·G TerenghiS R Bloom
Mar 1, 1985·Neuroscience·P K MulderryS R Bloom
Jul 1, 1984·The Journal of Laryngology and Otology·J Ylikoski
Jan 1, 1988·Eye·W G Unger, J M Butler
Jan 1, 1985·Journal of Ocular Pharmacology·W G UngerS R Bloom
Jan 1, 1990·Journal of Ocular Pharmacology·W G Unger
Aug 1, 1984·Acta Physiologica Scandinavica·S F Nilsson, A Bill
Apr 30, 1992·Annals of the New York Academy of Sciences·W G Unger
Feb 24, 2001·Anatomia, histologia, embryologia·C CavallottiE Pacella
Jan 1, 1985·Critical Reviews in Clinical Laboratory Sciences·J BallestaJ M Polak
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·J M AllenS R Bloom
Oct 15, 1990·The Journal of Comparative Neurology·S Kuchiiwa
Jan 1, 1990·Urology·J M AllenS R Bloom
Dec 1, 1984·Experimental Eye Research·R N Williams, P Bhattacherjee

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