Mapping quantitative trait Loci interactions from the maternal and offspring genomes

Genetics
Yuehua CuiRongling Wu

Abstract

The expression of most developmental or behavioral traits involves complex interactions between quantitative trait loci (QTL) from the maternal and offspring genomes. The maternal-offspring interactions play a pivotal role in shaping the direction and rate of evolution in terms of their substantial contribution to quantitative genetic (co)variation. To study the genetics and evolution of maternal-offspring interactions, a unifying statistical framework that embraces both the direct and indirect genetic effects of maternal and offspring QTL on any complex trait is developed. This model is derived for a simple backcross design within the maximum-likelihood context, implemented with the EM algorithm. Results from extensive simulations suggest that this model can provide reasonable estimation of additive and dominant effects of the QTL at different generations and their interaction effects derived from the maternal and offspring genomes. Although our model is framed to characterize the actions and interactions of maternal and offspring QTL affecting offspring traits, the idea can be readily extended to decipher the genetic machinery of maternal traits, such as maternal care. Our model provides a powerful means for studying the evol...Continue Reading

References

May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·K G LarkJ H Orf
Nov 1, 1994·Genetics·G A Churchill, R W Doerge
Mar 15, 2000·Nature·J P Vielle-CalzadaU Grossniklaus
Feb 24, 2001·Evolution; International Journal of Organic Evolution·J B Wolf
Dec 14, 2001·Nature·D WeijersG Jürgens
Nov 28, 2002·Genetics·Andréa C PeripatoJames M Cheverud
Jan 31, 2003·Nature·Reinmar Hager, Rufus A Johnstone
Mar 18, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jason B Wolf
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·James M Cheverud
Aug 19, 2008·The American Naturalist·Andréa C Peripato, James M Cheverud
Feb 1, 1998·Trends in Ecology & Evolution·J B WolfM J Wade

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Citations

Dec 6, 2011·Briefings in Bioinformatics·Xiyang ZhaoRongling Wu
Feb 25, 2005·Bioinformatics·Yuehua Cui, Rongling Wu
Jan 15, 2009·The American Naturalist·Timothy A LinksvayerRobert E Page
Jun 24, 2009·Trends in Plant Science·Xuefeng WangBrian A Larkins
Jun 15, 2007·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Yongxian Wen, Weiren Wu
May 1, 2012·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Timothy A LinksvayerManfred D Laubichler
Mar 17, 2015·Physics of Life Reviews·Lidan Sun, Rongling Wu

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