Mapping quantitative traits and strategies to find quantitative trait genes.

Methods : a Companion to Methods in Enzymology
Jonathan Flint

Abstract

In 1999 a meeting took place at the Jackson Laboratory, a large mouse research centre in Bar Harbor, Maine, to consider the value of systematically collecting phenotypes on inbred strains of mice (Paigen and Eppig (2000) [1]). The group concluded that cataloguing the extensive phenotypic diversity present among laboratory mice, and in particular providing the research community with data from cohorts of animals, phenotyped according to standardized protocols, was essential if we were to take advantage of the possibilities of mouse genetics. Beginning with the collection of basic physiological, biochemical and behavioral data on nine commonly used inbred strains, the project has expanded so that by the beginning of 2010 data for 178 strains had been collected, with 105 phenotype projects yielding over 2000 different measurements (Bogue et al. (2007) [2].

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Citations

Jul 16, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Clarissa C ParkerAbraham A Palmer
Jun 30, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Fiona McMurray, Roger D Cox
Jan 13, 2012·Behavior Genetics·Clarissa C ParkerAbraham A Palmer
Aug 23, 2011·Brain Research Bulletin·K R BowlesL Jones
Oct 29, 2011·Genes, Brain, and Behavior·C C ParkerA A Palmer
Apr 7, 2017·Disease Models & Mechanisms·Amelie Baud, Jonathan Flint
Aug 1, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Binnaz Yalcin, Jonathan Flint
Nov 9, 2011·Nature Reviews. Genetics·Andres Bendesky, Cornelia I Bargmann
Jan 25, 2014·Expert Opinion on Therapeutic Patents·Waleed M HusseinIstvan Toth
Sep 3, 2018·Molecular Genetics and Genomics : MGG·Jimmy ObalaRajeev K Varshney
Apr 25, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Joshua T YuanClarissa C Parker

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Methods Mentioned

BETA
genotyping

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