PMID: 9539698May 16, 1998Paper

Mapping strain exerted on blood vessel walls using deuterium double-quantum-filtered MRI

Proceedings of the National Academy of Sciences of the United States of America
Y SharfGil Navon

Abstract

A technique is described for displaying distinct tissue layers of large blood vessel walls as well as measuring their mechanical strain. The technique is based on deuterium double-quantum-filtered (DQF) spectroscopic imaging. The effectiveness of the double-quantum filtration in suppressing the signal of bulk water is demonstrated on a phantom consisting of rat tail tendon fibers. Only intrafibrillar water is displayed, excluding all other signals of water molecules that reorient isotropically. One- and two-dimensional spectroscopic imaging of bovine aorta and coronary arteries show the characteristic DQF spectrum of each of the tissue layers. This property is used to obtain separate images of the outer layer, the tunica adventitia, or the intermediate layer, the tunica media, or both. To visualize the effect of elongation, the average residual quadrupole splitting <delta nu q> is calculated for each pixel. Two-dimensional deuterium quadrupolar splitting images are obtained for a fully relaxed and a 55% elongated sample of bovine coronary artery. These images indicate that the strong effect of strain is associated with water molecules in the tunica adventitia whereas the DQF NMR signal of water in the tunica media is apparently...Continue Reading

References

Jan 1, 1993·Connective Tissue Research·W E Stehbens, B J Martin
Jan 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y SharfG Navon
Feb 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y AssafY Cohen
Jan 23, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L TsorefG Navon

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Citations

Sep 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Hadassah ShinarGil Navon
Apr 26, 2001·NMR in Biomedicine·G NavonY Seo
Dec 21, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Keren Keinan-AdamskyGil Navon
Jan 22, 2000·Molecular Aspects of Medicine·C Boesch
Jul 6, 2010·Experimental Cell Research·Soon-Mi LimAndreea Trache
Apr 10, 2014·Journal of Magnetic Resonance·Tatiana V Krivokhizhina, R J Wittebort
Jan 30, 2007·Journal of Magnetic Resonance Imaging : JMRI·G NavonB Blümich
Oct 31, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L TsorefG Navon
May 31, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·William PereaMichele Marcolongo
Feb 2, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Keren Keinan-AdamskyGil Navon
May 9, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A H AletrasG Navon
Sep 1, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y SeoG Navon
Mar 30, 2000·Journal of Magnetic Resonance Imaging : JMRI·L TsorefG Navon
Dec 12, 2012·The Journal of Physical Chemistry. B·Joel M Woudstra, Kristopher J Ooms

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