Mapping structural brain alterations in obsessive-compulsive disorder

Archives of General Psychiatry
Jesus PujolJulio Vallejo

Abstract

Recent technical developments have made it feasible to comprehensively assess brain anatomy in psychiatric populations. To describe the structural brain alterations detected in the magnetic resonance images of a large series of patients with obsessive-compulsive disorder (OCD) using imaging procedures that allow the evaluation of volume changes throughout the brain. Case-control study. Referral OCD unit in a tertiary hospital. A consecutive sample of 72 outpatients with OCD and 72 age- and sex-matched control subjects. Three-dimensional sequences were obtained in all participants. A statistical parametric mapping approach was used to delineate possible anatomical alterations in the entire brain. To preserve volumetric information, voxel values were modulated by the Jacobian determinants (volume change measurement) derived from spatial normalization. Voxelwise brain volumes. The brains of patients with OCD showed reduced gray matter volume in the medial frontal gyrus, the medial orbitofrontal cortex, and the left insulo-opercular region. A relative increase in gray matter volume was observed bilaterally in the ventral part of the putamen and in the anterior cerebellum. All these brain alterations were abnormally correlated in pa...Continue Reading

Citations

Sep 3, 2013·European Archives of Psychiatry and Clinical Neuroscience·Cinto SegalàsCarles Soriano-Mas
Apr 29, 2014·The Cerebellum·Matteo TonnaCarlo Marchesi
Feb 22, 2014·Medical Image Analysis·Emilio Parrado-HernándezCarles Soriano-Mas
Jun 26, 2013·Brain Structure & Function·Ziwen PengDinggang Shen
Nov 23, 2013·The British Journal of Psychiatry : the Journal of Mental Science·Esther ViaBen J Harrison
Dec 25, 2013·Biological Psychiatry·Froukje E de VriesOdile A van den Heuvel
Mar 19, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giovanni BattistellaChristian Giroud
Jan 5, 2008·The British Journal of Psychiatry : the Journal of Mental Science·James WoolleyKatya Rubia
Nov 3, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Joaquim Radua, David Mataix-Cols
Sep 18, 2008·Neuroreport·Veena M NarayanPhilip R Szeszko
Oct 8, 2008·Development and Psychopathology·Tiago V MaiaBradley S Peterson
Nov 6, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jean-Yves RotgePierre Burbaud
Nov 17, 2009·Cerebral Cortex·Dara G GhahremaniRussell A Poldrack
Jan 30, 2010·European Archives of Psychiatry and Clinical Neuroscience·Thomas WobrockThomas William Moorhead
Sep 9, 2010·Brain : a Journal of Neurology·Anouk den BraberEco J C de Geus
Oct 23, 2010·Journal of Psychiatry & Neuroscience : JPN·Tijiang ZhangQiyong Gong
Dec 2, 2010·Journal of Psychiatry & Neuroscience : JPN·Emre BoraMurat Yücel
Mar 9, 2011·Archives of General Psychiatry·Alexandre BerneyChawki Benkelfat
Jan 1, 2009·Indian Journal of Psychological Medicine·Ganesan VenkatasubramanianRishikesh V Behere
Oct 28, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marcelo Queiroz HoexterGeraldo Filho Busatto
Nov 19, 2013·PloS One·Chantale MontignyUNKNOWN IMAGEN Consortium
May 12, 2012·Brain Structure & Function·C Soriano-MasN Cardoner
Jul 25, 2012·Brain Connectivity·Jan Carl BeuckeNorbert Kathmann
Aug 4, 2012·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Anouk den BraberEco J C de Geus
Mar 27, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Anouk den BraberDennis van 't Ent
Jun 14, 2005·Schizophrenia Research·Serge A MitelmanMonte S Buchsbaum
Oct 28, 2008·Brain : a Journal of Neurology·Odile A van den HeuvelDick J Veltman
Jul 15, 2015·International Journal of Psychiatry in Clinical Practice·Murad AtmacaHakan Turkcapar
Feb 13, 2009·Expert Review of Neurotherapeutics·Jun Soo KwonDo-Hyung Kang
Aug 14, 2009·Expert Review of Neurotherapeutics·Samuel R Chamberlain, Lara Menzies
Feb 1, 2012·Expert Review of Neurotherapeutics·Alexandra M RodmanDarin D Dougherty
Dec 16, 2009·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Athanassios DouzenisLefteris Lykouras
Jul 26, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Narcís CardonerJosé M Menchón
Feb 7, 2016·Psychiatry Research. Neuroimaging·Yasutaka KubotaMotomi Toichi
Dec 29, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Xinyu HuXiaoqi Huang
Dec 3, 2015·Depression and Anxiety·Clara López-SolàBen J Harrison
Oct 26, 2012·L'Encéphale·M DupuyC Bungener

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