Mapping the 3D Connectivity of the Rat Inner Retinal Vascular Network Using OCT Angiography

Investigative Ophthalmology & Visual Science
Conor LeahyVivek J Srinivasan

Abstract

The purpose of this study is to demonstrate three-dimensional (3D) graphing based on optical coherence tomography (OCT) angiography for characterization of the inner retinal vascular architecture and determination of its topologic principles. Rat eyes (N = 3) were imaged with a 1300-nm spectral/Fourier domain OCT microscope. A topologic model of the inner retinal vascular network was obtained from OCT angiography data using a combination of automated and manually-guided image processing techniques. Using a resistive network model, with experimentally-quantified flow in major retinal vessels near the optic nerve head as boundary conditions, theoretical changes in the distribution of flow induced by vessel dilations were inferred. A topologically-representative 3D vectorized graph of the inner retinal vasculature, derived from OCT angiography data, is presented. The laminar and compartmental connectivity of the vasculature are characterized. In contrast to sparse connectivity between the superficial vitreal vasculature and capillary plexuses of the inner retina, connectivity between the two capillary plexus layers is dense. Simulated dilation of single arterioles is shown to produce both localized and lamina-specific changes in b...Continue Reading

Citations

Mar 8, 2016·Experimental Eye Research·Maged AlnawaisehNicole Eter
Jul 9, 2016·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·J H MeyerS Schmitz-Valckenberg
Aug 4, 2018·Investigative Ophthalmology & Visual Science·Peter L Nesper, Amani A Fawzi
Apr 18, 2019·Investigative Ophthalmology & Visual Science·Corey A SmithBalwantray C Chauhan
Feb 8, 2020·Investigative Ophthalmology & Visual Science·Da ZhaoBang V Bui
May 12, 2020·Investigative Ophthalmology & Visual Science·Sonja G KarstEduardo V Navajas
Mar 16, 2018·Biomedical Optics Express·Marcel T BernucciVivek J Srinivasan
Jun 20, 2020·Proceedings of the National Academy of Sciences of the United States of America·Vivek J Srinivasan, Ala Moshiri
Feb 11, 2020·Journal of X-ray Science and Technology·Hui-Hong DuanSheng-Dong Nie

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