Mapping the antigenic and genetic evolution of influenza virus

Science
Derek J SmithRon A M Fouchier

Abstract

The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated than genetic evolution, and genetic change sometimes had a disproportionately large antigenic effect. The method readily allows monitoring of antigenic differences among vaccine and circulating strains and thus estimation of the effects of vaccination. Further, this approach offers a route to predicting the relative success of emerging strains, which could be achieved by quantifying the combined effects of population level immune escape and viral fitness on strain evolution.

References

Jul 6, 1978·Journal of Theoretical Biology·L Edelstein, R Rosen
Apr 1, 1996·The Journal of General Virology·J M DalyJ A Mumford
Nov 11, 1999·Molecular Biology and Evolution·R M BushN J Cox
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·D J SmithA S Perelson
Dec 3, 1999·Science·R M BushW M Fitch
Jun 10, 2000·Science·B KorberT Bhattacharya
Aug 31, 2001·Journal of Theoretical Biology·A Lapedes, R Farber
Jan 10, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A J HayY P Lin
Apr 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Joshua B PlotkinSimon A Levin
Jul 24, 2002·Proceedings of the National Academy of Sciences of the United States of America·Edwin D KilbourneNancy Cox
Sep 11, 2002·The Lancet Infectious Diseases·Klaus Stöhr
Dec 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Julia R Gog, Bryan T Grenfell
Mar 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Douglas D RichmanChristos J Petropoulos
Mar 28, 2003·Nature·Neil M FergusonRobin M Bush
Sep 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Julia R GogBryan T Grenfell
Jan 17, 2004·Science·Bryan T GrenfellEdward C Holmes

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Citations

Sep 6, 2008·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·B Biere, B Schweiger
May 28, 2008·Journal of Molecular Evolution·Rubing Chen, Edward C Holmes
Sep 8, 2006·Archives of Virology·M J GibbsA J Gibbs
Mar 23, 2010·Archives of Virology·Nazanin Zahra Shafiei JandaghiRakhshandeh Nategh
Aug 19, 2007·Journal of Community Health·James RansomCynthia Phillips
Jan 16, 2014·Indian Journal of Virology : an Official Organ of Indian Virological Society·S BhatiaR Sood
Apr 24, 2013·Journal of Theoretical Biology·Lisa N MurilloAlan S Perelson
Jun 6, 2013·Virus Research·Stephanie SonnbergRobert G Webster
Aug 7, 2013·Virus Research·Mary J Pantin-Jackwood, David L Suarez
Jul 2, 2010·Animal Health Research Reviews·Heather L Forrest, Robert G Webster
Apr 18, 2008·Nature·Andrew RambautEdward C Holmes
Jun 4, 2013·Nature Biotechnology·Alejandro B BalazsDavid Baltimore
Sep 13, 2011·Nature Chemical Biology·Miguel A MataBeatriz M A Fontoura
Jan 17, 2008·Nature Reviews. Microbiology·Gunilla B Karlsson HedestamRichard T Wyatt
May 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Wilfred NdifonSimon A Levin
Feb 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ming-Wei ChenChi-Huey Wong
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Caroline O BuckeeSunetra Gupta
Nov 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Virginia E PitzerBryan T Grenfell
Feb 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nimalan ArinaminpathyBryan T Grenfell
Dec 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Matthew R SandbulteMaryna C Eichelberger
Jan 19, 2013·The Journal of Biological Chemistry·Stevan A Springer, Pascal Gagneux
Aug 10, 2012·Journal of Biological Dynamics·Maia Martcheva
May 25, 2013·Journal of Biological Dynamics·Jorge A Alfaro-MurilloZhilan Feng
Sep 12, 2009·The Journal of Infectious Diseases·Matthew J MemoliJeffery K Taubenberger
Nov 4, 2011·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Fabian L WauthierNebojsa Jojic
Nov 9, 2006·Bioinformatics·Alexander P GultyaevRené C L Olsthoorn
Jan 12, 2008·Bioinformatics·Yu-Chieh LiaoChao A Hsiung
Apr 15, 2010·Bioinformatics·William D LeesAdrian J Shepherd
Mar 9, 2012·Bioinformatics·J Lamar BarnettXiu-Feng Wan
May 31, 2008·Molecular Biology and Evolution·Sergei L Kosakovsky PondSimon D W Frost
Mar 20, 2012·Molecular Biology and Evolution·Christina TuscheAlice C McHardy
Sep 5, 2013·Molecular Biology and Evolution·Teruaki Watabe, Hirohisa Kishino
Nov 19, 2008·Nucleic Acids Research·In Seok YangKyung Hyun Kim
May 12, 2009·Nucleic Acids Research·Yu-Chieh LiaoChao A Hsiung

❮ Previous
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