Mapping the asynchrony of cortical maturation in the infant brain: A MRI multi-parametric clustering approach

NeuroImage
J LebenbergJessica Dubois

Abstract

While the main neural networks are in place at term birth, intense changes in cortical microstructure occur during early infancy with the development of dendritic arborization, synaptogenesis and fiber myelination. These maturational processes are thought to relate to behavioral acquisitions and the development of cognitive abilities. Nevertheless, in vivo investigations of such relationships are still lacking in healthy infants. To bridge this gap, we aimed to study the cortical maturation using non-invasive Magnetic Resonance Imaging, over a largely unexplored period (1-5 post-natal months). In a first univariate step, we focused on different quantitative parameters: longitudinal relaxation time (T1), transverse relaxation time (T2), and axial diffusivity from diffusion tensor imaging (λ//) These individual maps, acquired with echo-planar imaging to limit the acquisition time, showed spatial distortions that were first corrected to reliably match the thin cortical ribbon identified on high-resolution T2-weighted images. Averaged maps were also computed over the infants group to summarize the parameter characteristics during early infancy. In a second step, we considered a multi-parametric approach that leverages parameters co...Continue Reading

Citations

May 19, 2020·Journal of Magnetic Resonance Imaging : JMRI·Jessica DuboisManon J N L Benders
Jan 17, 2020·Brain : a Journal of Neurology·Jonathan O'MuircheartaighA David Edwards
Jun 17, 2020·Cerebral Cortex·Daphna FenchelJonathan O'Muircheartaigh
May 28, 2019·Frontiers in Neural Circuits·Robert Turner
Sep 16, 2020·Methods : a Companion to Methods in Enzymology·Xingzhong Zhao, Xing-Ming Zhao
Mar 7, 2020·Neuron·George A MashourStanislas Dehaene
May 27, 2021·Seminars in Cell & Developmental Biology·Anne Teissier, Alessandra Pierani
Jul 30, 2021·Frontiers in Neuroscience·Anni CopelandJetro J Tuulari
Oct 16, 2021·Communications Biology·Vaidehi S NatuKalanit Grill-Spector
Dec 7, 2021·Frontiers in Neuroscience·Justin L BalsorKathryn M Murphy

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