Mapping the brain pathways of traumatic memory: inactivation of protein kinase M zeta in different brain regions disrupts traumatic memory processes and attenuates traumatic stress responses in rats

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Hagit CohenJoseph Zohar

Abstract

Protein kinase M zeta (PKMzeta), a constitutively active isoform of protein kinase C, has been implicated in protein synthesis-dependent maintenance of long-term potentiation and memory storage in the brain. Recent studies reported that local application of ZIP, a membrane-permeant PKMzeta inhibitor, into the insular cortex (IC) of behaving rats abolished long-term memory of taste associations. This study assessed the long-term effects of local applications of ZIP microinjected immediately (1 h) or 10 days after predator scent stress exposure, in a controlled prospectively designed animal model for PTSD. Four brain structures known to be involved in memory processes and in anxiety were investigated: lateral ventricle (LV), dorsal hippocampus (DH), basolateral amygdala and IC. The outcome measures included behavior in an elevated plus maze and acoustic startle response 7 days after microinjection, and freezing behavior upon exposure to trauma-related cue 8 days after microinjection. Previously acquired/encoded memories associated with the IC were also assessed. Inactivation of PKMzeta in the LV or DH within 1h of exposure effectively reduced PTSD-like behavioral disruption and trauma cue response 8 days later. Inactivation of PK...Continue Reading

References

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Citations

Jun 1, 2013·Psychopharmacology·M TothV B Risbrough
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Iván HernándezTodd Charlton Sacktor
Sep 19, 2012·Molecular Brain·Todd Charlton Sacktor
Feb 26, 2013·Molecular Pain·Theodore J Price, Sourav Ghosh
Mar 4, 2014·Physiology & Behavior·Rie RyokeYukio Ichitani
Feb 4, 2014·Journal of Neuroscience Methods·Tine L Gulbrandsen, Robert J Sutherland
Nov 20, 2012·Pharmacology, Biochemistry, and Behavior·Jennifer L Szczytkowski-ThomsonDonald T Lysle
May 25, 2013·The International Journal of Neuropsychopharmacology·Artur PałaszRyszard Wiaderkiewicz
Aug 12, 2016·Experimental Neurology·Judith K Daniels, Eric Vermetten
Jan 31, 2017·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Salman Zubedat, Irit Akirav
Jul 16, 2013·Current Protocols in Neuroscience·Hagit CohenZohar Joseph

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