Abstract
Protein kinase M zeta (PKMzeta), a constitutively active isoform of protein kinase C, has been implicated in protein synthesis-dependent maintenance of long-term potentiation and memory storage in the brain. Recent studies reported that local application of ZIP, a membrane-permeant PKMzeta inhibitor, into the insular cortex (IC) of behaving rats abolished long-term memory of taste associations. This study assessed the long-term effects of local applications of ZIP microinjected immediately (1 h) or 10 days after predator scent stress exposure, in a controlled prospectively designed animal model for PTSD. Four brain structures known to be involved in memory processes and in anxiety were investigated: lateral ventricle (LV), dorsal hippocampus (DH), basolateral amygdala and IC. The outcome measures included behavior in an elevated plus maze and acoustic startle response 7 days after microinjection, and freezing behavior upon exposure to trauma-related cue 8 days after microinjection. Previously acquired/encoded memories associated with the IC were also assessed. Inactivation of PKMzeta in the LV or DH within 1h of exposure effectively reduced PTSD-like behavioral disruption and trauma cue response 8 days later. Inactivation of PK...Continue Reading
References
Aug 1, 1992·Behavioral Neuroscience·J J KimJ Landeira-Fernandez
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·F Bermudez-RattoniJ L McGaugh
Dec 1, 1993·Physiology & Behavior·S E FileP S Mabbutt
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T C SacktorE Sublette
Jul 1, 1996·Neurobiology of Learning and Memory·L NeradF Bermúdez-Rattoni
Jan 11, 2000·Critical Care Medicine·G SchellingJ Briegel
Dec 26, 2001·Chemical Reviews·A C Newton
Jul 9, 2003·Critical Care Medicine·Gustav SchellingHans-Peter Kapfhammer
Oct 24, 2003·Biological Psychiatry·Guillaume VaivaCharles R Marmar
Mar 12, 2004·Biological Psychiatry·Gustav SchellingHans-Peter Kapfhammer
Jul 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hagit CohenGal Richter-Levin
Aug 3, 2004·The American Journal of Psychiatry·Amanda AerniDominique J-F de Quervain
Jun 28, 2005·Biological Psychiatry·Hagit CohenAmir B Geva
Aug 17, 2005·Physiology & Behavior·Robert AdamecPaul Burton
Feb 8, 2006·Hippocampus·Douglas S F LingTodd C Sacktor
Jun 1, 2006·Biological Psychiatry·Hagit CohenJoseph Zohar
Aug 8, 2006·Annals of the New York Academy of Sciences·Hagit CohenJoseph Zohar
Aug 26, 2006·Science·Tim V P BlissSerge Laroche
Aug 26, 2006·Science·Eva PastalkovaTodd Charlton Sacktor
Apr 10, 2007·European Psychiatry : the Journal of the Association of European Psychiatrists·M NagaiS Kato
Jul 28, 2007·The International Journal of Neuropsychopharmacology·Hagit CohenZeev Kaplan
Aug 19, 2007·Science·Reut ShemaYadin Dudai
Sep 28, 2007·The American Journal of Psychiatry·Amit Etkin, Tor D Wager
Jul 19, 2008·Biological Psychiatry·Hagit CohenJoseph Zohar
Dec 9, 2008·Biological Psychiatry·Richard A BryantAlexander C McFarlane
Citations
Jun 1, 2013·Psychopharmacology·M TothV B Risbrough
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Iván HernándezTodd Charlton Sacktor
Sep 19, 2012·Molecular Brain·Todd Charlton Sacktor
May 13, 2014·Archives of Oral Biology·Yinzi XinChufeng Liu
Feb 26, 2013·Molecular Pain·Theodore J Price, Sourav Ghosh
Jul 30, 2011·Trends in Neurosciences·Amy L Mahan, Kerry J Ressler
Sep 3, 2014·Behavioral and Brain Functions : BBF·Li-Li JiZhen-Yu Wang
Jan 30, 2013·Neuropharmacology·Isabella PanaccioneZafar I Bashir
Mar 4, 2014·Physiology & Behavior·Rie RyokeYukio Ichitani
Feb 4, 2014·Journal of Neuroscience Methods·Tine L Gulbrandsen, Robert J Sutherland
May 23, 2014·Behavioural Brain Research·Hui LiHaifeng Zhai
Nov 20, 2012·Pharmacology, Biochemistry, and Behavior·Jennifer L Szczytkowski-ThomsonDonald T Lysle
May 25, 2013·The International Journal of Neuropsychopharmacology·Artur PałaszRyszard Wiaderkiewicz
Aug 12, 2016·Experimental Neurology·Judith K Daniels, Eric Vermetten
Jan 31, 2017·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Salman Zubedat, Irit Akirav
Nov 29, 2017·Molecular Psychiatry·W YanL Lu
Jul 16, 2013·Current Protocols in Neuroscience·Hagit CohenZohar Joseph
Jul 26, 2011·Learning & Memory·Fernando Gámiz, Milagros Gallo