Mapping the cancer-specific QLQ-C30 onto the generic EQ-5D-5L and SF-6D in colorectal cancer patients

Expert Review of Pharmacoeconomics & Outcomes Research
Hosein AmeriAli Akbari Sari

Abstract

Economic evaluation of healthcare interventions usually needs accurate data on utility and health-related quality-of-life scores. The aim of this study is to map QLQ-C30 scale score onto EQ-5D-5L and SF-6D utility values in colorectal cancer (CRC) patients. EQ-5D-5L, SF-6D, and QLQ-C30 were completed by 252 patients with CRC who were referred to three cancer centers in Tehran between May and September 2017. Moreover, OLS, Tobit, and CLAD models were used to predict EQ-5D-5L and SF-6D values. The goodness of fit of models was evaluated using Pred R2 and Adj R2. In addition, their predictive performance was assessed by MAE, RMSE, ICC, MID, and Spearman's correlation coefficients between observed and predicted EQ-5D-5L and SF-6D values. Models were validated using a 10-fold cross-validation method. Considering the goodness of fit and predictive ability of models, the OLS Model 2 performed best for EQ-5D-5L (Adj R2 = 58.09%, Pred R2 = 58.93%, MAE = 0.0932, RMSE = 0.129) and the OLS Model 3 performed best for SF-6D (Adj R2 = 54.90%, Pred R2 = 55.62%, MAE = 0.0485, RMSE = 0.0634). Our results demonstrated that algorithms developed based on OLS Models 1 and 2 are the best for predicted EQ-5D-5L and SF-6D values, respectively.

References

Sep 29, 1999·Statistical Methods in Medical Research·J M Bland, D G Altman
Oct 29, 1999·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·A MontazeriM Haji-Mahmoodi
Apr 10, 2002·Journal of Health Economics·John BrazierMark Deverill
Nov 14, 2003·Health and Quality of Life Outcomes·John HorsmanGeorge Torrance
Aug 23, 2005·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Stephen J Walters, John E Brazier
Jun 5, 2007·Medical Decision Making : an International Journal of the Society for Medical Decision Making· Nan LuoStephen Joel Coons
Jul 19, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Lynda McKenzie, Marjon van der Pol
Sep 12, 2008·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Yin-Bun CheungCynthia Goh
Jun 30, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Nick KontodimopoulosDimitris Niakas
Jul 9, 2009·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·John E BrazierDonna Louise Rowen
May 18, 2010·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Ralph Crott, Andrew Briggs
Mar 1, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Stefan SauerlandMarc Immenroth
May 16, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Carlos K H WongJanice Tsang
Dec 19, 2012·Health and Quality of Life Outcomes·Seon Ha KimJin-Hee Ahn
Dec 19, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Annie HawtonDave Wright
Jan 23, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Louise Longworth, Donna Rowen
Mar 30, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Carlos King Ho WongDonna Rowen
Nov 14, 2013·Expert Review of Pharmacoeconomics & Outcomes Research·Helen McTaggart-CowanStuart Peacock
Dec 3, 2013·Health and Quality of Life Outcomes·Paulos TeckleStuart Peacock
Mar 13, 2014·Health and Quality of Life Outcomes·Irina ProskorovskyFaith E Davies
Apr 5, 2015·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Gang ChenJeff Richardson
Apr 14, 2016·Health and Quality of Life Outcomes·Iftekhar KhanJoe Maguirre
Jun 23, 2016·Journal of Chiropractic Medicine·Terry K Koo, Mae Y Li
Sep 28, 2016·Journal of Medical Economics·Emily-Ruth MarriottAnthony J Hatswell
Nov 25, 2016·Value in Health Regional Issues·Pei WangJulian Thumboo
Jan 7, 2018·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Monica Hernandez AlavaLisa Irvine

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Citations

Jul 28, 2020·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Azin NahvijouHosein Ameri
Apr 13, 2019·Journal of Gastrointestinal Cancer·Hosein AmeriAli Akbari Sari
Oct 28, 2020·Expert Review of Pharmacoeconomics & Outcomes Research·Hosein AmeriThomas Poder
Oct 30, 2020·Osong Public Health and Research Perspectives·Morteza Arab-ZozaniHosein Ameri
Nov 5, 2020·Health and Quality of Life Outcomes·Yasuhiro HagiwaraKojiro Shimozuma
Mar 28, 2021·Value in Health Regional Issues·Maral Seyed AhadiZeinab Ghorbani
May 18, 2021·SAGE Open Medicine·Forouzan ZareMohammad Reza Aghaei
Sep 24, 2021·Applied Health Economics and Health Policy·Aurelie MeunierLouise Longworth
Dec 1, 2021·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Richard Huan XuShuyang Zhang

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