Mapping the chromosome 16 cadherin gene cluster to a minimal deleted region in ductal breast cancer

Cancer Genetics and Cytogenetics
I J ChalmersM J Atkinson

Abstract

The cadherin family of cell adhesion molecules has been implicated in tumor metastasis and progression. Eight family members have been mapped to the long arm of chromosome 16. Using radiation hybrid mapping, we have located six of these genes within a cluster at 16q21-q22.1. In invasive lobular carcinoma of the breast frequent LOH and accompanying mutation affect the CDH1 gene, which is a member of this chromosome 16 gene cluster. CDH1 LOH also occurs in invasive ductal carcinoma, but in the absence of gene mutation. The proximity of other cadherin genes to 16q22.1 suggests that they may be affected by LOH in invasive ductal carcinomas. Using the mapping data, microsatellite markers were selected which span regions of chromosome 16 containing the cadherin genes. In breast cancer tissues, a high rate of allelic loss was found over the gene cluster region, with CDH1 being the most frequently lost marker. In invasive ductal carcinoma a minimal deleted region was identified within part of the chromosome 16 cadherin gene cluster. This provides strong evidence for the existence of a second 16q22 suppressor gene locus within the cadherin cluster.

References

Sep 1, 1992·The Journal of Cell Biology·M G LampugnaniE Dejana
Jul 19, 1995·Journal of the National Cancer Institute·K F Becker, H Höfler
Nov 1, 1995·Genes, Chromosomes & Cancer·F Dorion-BonnetM Longy
Mar 1, 1997·Cell Adhesion and Communication·R B HazanP I Borgen
Dec 31, 1997·The Journal of Cell Biology·G L RadiceR O Hynes

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Citations

Mar 4, 2006·BMC Cancer·José Roberto F CaldeiraSilvia R Rogatto
Dec 18, 2015·Computational Biology and Chemistry·María Florencia AbascalMónica Hebe Vazquez-Levin
Oct 7, 2008·Genes, Chromosomes & Cancer·Berna DemircanKevin D Brown
May 18, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cathy B MoelansPaul J van Diest
Mar 31, 2004·The Journal of Biological Chemistry·Norma MarchesiniYusuf A Hannun

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