Mapping the functional connectivity of the substantia nigra, red nucleus and dentate nucleus: A network analysis hypothesis associated with the extrapyramidal system

Neuroscience Letters
Hong-ying ZhangBing Guan

Abstract

This study aimed to examine the functional networks related to the extrapyramidal system using a temporal oscillation signal correlation analysis method based on critical nodes in the substantia nigra (SN), red nucleus (RN) and dentate nucleus (DN). Nineteen healthy subjects underwent resting-state fMRI and susceptibility weighted imaging (SWI). For the brain network analysis, the SN, RN and DN were positioned on susceptibility weighted images and used as seeds for temporal correlations analyzed via BOLD data. T-tests were performed for the correlation coefficients of each seed. We demonstrated that the SN, RN and DN were functionally connected to each other, and, in general, their connectivity maps overlapped in a series of subcortical extrapyramidal structures and regions of cerebral cortices. A Granger causality analysis indicated that the effective connectivity graphs within extrapyramidal structures mainly exhibited a spacial up-down pattern for the positive and negative influences, respectively. Our findings suggest that extensive regions involved in the extrapyramidal system constituted a relatively exclusive network via spatial-temporal correlation signals that analogously corresponded to the anatomical structures. The ...Continue Reading

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Citations

Aug 11, 2016·Frontiers in Human Neuroscience·Alberto CacciolaAngelo Quartarone
Nov 13, 2019·The Journal of Headache and Pain·Xiaobin HuangXindao Yin
Nov 12, 2016·Frontiers in Neuroinformatics·Jian ZhangTianzi Jiang
Nov 13, 2020·Brain Structure & Function·Gianpaolo Antonio BasileAlberto Cacciola
Jun 5, 2021·Human Brain Mapping·Fulvia PalesiClaudia A M Gandini Wheeler-Kingshott
Jun 29, 2021·Frontiers in Neuroscience·Rafael Olivares-MorenoGerardo Rojas-Piloni
Sep 26, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Hidehiro IshikawaHidekazu Tomimoto

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