Mapping the journey from totipotency to lineage specification in the mouse embryo

Current Opinion in Genetics & Development
Chuen Yan Leung, Magdalena Zernicka-Goetz

Abstract

Understanding the past is to understand the present. Mammalian life, with all its complexity comes from a humble beginning of a single fertilized egg cell. Achieving this requires an enormous diversification of cellular function, the majority of which is generated through a series of cellular decisions during embryogenesis. The first decisions are made as the embryo prepares for implantation, a process that will require specialization of extra-embryonic lineages while preserving an embryonic one. In this mini-review, we will focus on the mouse as a mammalian model and discuss recent advances in the decision making process of the early embryo.

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Citations

Mar 4, 2017·Science·Sarah Ellys HarrisonMagdalena Zernicka-Goetz
Mar 27, 2018·Biology of Reproduction·R Michael RobertsYing Yang
Jun 16, 2019·Biology of Reproduction·Mahboobeh AmoushahiKarin Lykke-Hartmann
Apr 5, 2017·Stem Cells International·Gregory M Kelly, Mohamed I Gatie
Apr 25, 2018·Nature Reviews. Molecular Cell Biology·Melanie A Eckersley-MaslinWolf Reik
Oct 7, 2020·International Journal of Molecular Sciences·Jong-Nam OhChang-Kyu Lee
Apr 13, 2021·Molecular Reproduction and Development·Mariagrazia PaonessaGiovanni Coticchio

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