Mapping the oculomotor system

Progress in Brain Research
Jean A Büttner-Ennever

Abstract

Over the last three decades and together with Bernard Cohen, Volker Henn, Ulrich Büttner, and Anja Horn, it has been possible to morphologically identify several functional cell groups in the oculomotor system: the medium-sized horizontal excitatory and inhibitory burst neurons (EBNs, IBNs) in the paramedian pontine reticular formation (PPRF), the more sparsely scattered vertical EBNs in the rostral interstitial nucleus of the MLF (RIMLF), and the typically elongated omnipause neurons (OPNs) in nucleus raphé interpositus--all essential for the generation of saccades. In contrast, the role of the central mesencephalic reticular formation (cMRF) in saccades is more complex, as is the morphological outlining of its borders. A detailed study of the extraocular motoneurons showed that they can be divided into two separate types: those for singly innervated (twitch) muscle fibres (SIFs) and those for multiply innervated (non-twitch) muscle fibres (MIFs). The two motoneuron types receive different premotor afferents, proving that MIF and SIF motoneurons have different functions. The cell groups were outlined by different tract tracing methods including rabies virus. The localization and histochemical characterization of all these func...Continue Reading

Citations

Mar 1, 2011·Brain : a Journal of Neurology·Pamela FederighiAlessandra Rufa
Aug 26, 2014·Journal of Neurology·M StruppT Bremova
Nov 4, 2017·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Seung-Han LeeJi-Soo Kim
Dec 15, 2010·Current Opinion in Neurology·Alessandro SerraR John Leigh
Apr 13, 2013·Alcoholism, Clinical and Experimental Research·Angelina PaolozzaJames N Reynolds
Jan 27, 2019·Cerebellum & Ataxias·Kelsey JensenAasef G Shaikh
Sep 29, 2011·Annals of the New York Academy of Sciences·Aasef G ShaikhR John Leigh
Sep 29, 2011·Annals of the New York Academy of Sciences·Alessandra Rufa, Pamela Federighi
Jan 1, 2017·Expert Review of Ophthalmology·Sushant Puri, Aasef G Shaikh
Oct 1, 2012·Expert Review of Ophthalmology·Aasef G Shaikh
Aug 17, 2018·BioMed Research International·Alberto BaldiniSimona Tecco
Jun 8, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Tatiana Bremova-ErtlMichael Strupp

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.