Mapping the self in the brain's default mode network

NeuroImage
Christopher G DaveyBen J Harrison

Abstract

The brain's default mode network (DMN) has become closely associated with self-referential mental activity, particularly in the resting-state. While the DMN is important for such processes, it has functions other than self-reference, and self-referential processes are supported by regions outside of the DMN. In our study of 88 participants, we examined self-referential and resting-state processes to clarify the extent to which DMN activity was common and distinct between the conditions. Within areas commonly activated by self-reference and rest we sought to identify those that showed additional functional specialization for self-referential processes: these being not only activated by self-reference and rest but also showing increased activity in self-reference versus rest. We examined the neural network properties of the identified 'core-self' DMN regions-in medial prefrontal cortex (MPFC), posterior cingulate cortex (PCC), and inferior parietal lobule-using dynamic causal modeling. The optimal model identified was one in which self-related processes were driven via PCC activity and moderated by the regulatory influences of MPFC. We thus confirm the significance of these regions for self-related processes and extend our unders...Continue Reading

References

Jul 1, 1968·Journal of Personality and Social Psychology·N H Anderson
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Aug 9, 2002·Journal of Cognitive Neuroscience·W M KelleyT F Heatherton
May 6, 2003·Journal of Cognitive Neuroscience·Kristen A McKiernanJeffrey R Binder
Sep 2, 2003·NeuroImage·K J FristonW Penny
Jun 29, 2004·NeuroImage·W D PennyK J Friston
Mar 24, 2005·NeuroImage·Arnaud D'ArgembeauEric Salmon
Nov 5, 2005·NeuroImage·Kristen A McKiernanJeffrey R Binder
Jan 10, 2006·Brain : a Journal of Neurology·Andrea E Cavanna, Michael R Trimble
Sep 23, 2006·Journal of Cognitive Neuroscience·J M MoranW M Kelley
Jan 20, 2007·Science·Malia F MasonC Neil Macrae
Apr 4, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Paul W BurgessIroise Dumontheil
Jun 6, 2007·Trends in Cognitive Sciences·Paul W BurgessSam J Gilbert
Jul 4, 2008·PLoS Biology·Patric HagmannOlaf Sporns
Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ben J HarrisonNarcís Cardoner
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Devarajan SridharanVinod Menon
Nov 6, 2008·Social Cognitive and Affective Neuroscience·Todd F HeathertonWilliam M Kelley
Mar 25, 2009·NeuroImage·Klaas Enno StephanKarl J Friston
Mar 20, 2010·PLoS Computational Biology·Will D PennyAlex P Leff
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Nov 30, 2010·NeuroImage·Susan Whitfield-GabrieliJohn D E Gabrieli
Apr 6, 2011·PloS One·Francesca FerriVittorio Gallese
May 26, 2011·NeuroImage·Dardo Tomasi, Nora D Volkow
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Robin L Carhart-HarrisDavid J Nutt
Jul 23, 2013·Brain : a Journal of Neurology·Robert Leech, David J Sharp
Oct 1, 1997·Journal of Cognitive Neuroscience·G L ShulmanS E Petersen
Sep 11, 2013·NeuroImage·L RigouxJ Daunizeau
Sep 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Suresh D MuthukumaraswamyDavid J Nutt
Feb 20, 2014·Frontiers in Human Neuroscience·Robin L Carhart-HarrisDavid Nutt

❮ Previous
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Citations

Jul 21, 2016·Human Brain Mapping·Katharina FeldkerThomas Straube
Nov 23, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Esther ViaJosé M Menchón
Feb 28, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J M C van LeeuwenC H Vinkers
Sep 8, 2018·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Christopher G Davey, Ben J Harrison
Oct 6, 2018·The European Journal of Neuroscience·Shikha PrashadFrancesca M Filbey
Jan 16, 2019·Brain and Behavior·Marion A StopyraHans-Christoph Friederich
Apr 21, 2019·Brain and Behavior·Shigeyuki IkedaRyuta Kawashima
May 17, 2019·The Australian and New Zealand Journal of Psychiatry·Jooyoung OhJae-Jin Kim
Jun 22, 2019·Pharmacological Reviews·R L Carhart-Harris, K J Friston
Feb 16, 2018·Neurology·Joseph TherriaultUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 24, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·N L MasonJ G Ramaekers
May 17, 2018·Frontiers in Aging Neuroscience·Andrew C Peterson, Chiang-Shan R Li
Oct 20, 2018·Frontiers in Human Neuroscience·Andrea ScalabriniGeorg Northoff
Jan 15, 2019·International Journal of Bipolar Disorders·Kallia ApazoglouCamille Piguet
Sep 23, 2020·Cerebral Cortex·Trevor StewardBen J Harrison
May 15, 2018·Frontiers in Human Neuroscience·Andreas A Ioannides
Jul 26, 2018·Neuroscience of Consciousness·Chris Letheby, Philip Gerrans
Aug 9, 2018·Frontiers in Psychology·Jeff TarrantHannah Cope
Jan 30, 2019·Frontiers in Human Neuroscience·Florens GoldbeckAnn-Christine Ehlis
Jun 27, 2019·Pain·Marina López-SolàTor D Wager
Sep 12, 2019·Frontiers in Psychology·Ana Maria Cebolla, Guy Cheron
Aug 24, 2019·Scientific Reports·Seishu NakagawaRyuta Kawashima
Oct 6, 2020·Cognitive Neurodynamics·Claudio ImperatoriAntonios Dakanalis
Oct 2, 2020·Scientific Reports·Shaoming WangDavid V Smith
Feb 1, 2018·Social Cognitive and Affective Neuroscience·Liman Man Wai LiXiang Wu
Jun 28, 2018·Cognitive, Affective & Behavioral Neuroscience·Maureen D SatyshurJacqueline K Gollan

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