Mapping the Structure-Function Relationship in Glaucoma and Healthy Patients Measured with Spectralis OCT and Humphrey Perimetry

Journal of Ophthalmology
Laia JaumandreuGema Rebolleda

Abstract

To study the structure-function relationship in glaucoma and healthy patients assessed with Spectralis OCT and Humphrey perimetry using new statistical approaches. Eighty-five eyes were prospectively selected and divided into 2 groups: glaucoma (44) and healthy patients (41). Three different statistical approaches were carried out: (1) factor analysis of the threshold sensitivities (dB) (automated perimetry) and the macular thickness (μm) (Spectralis OCT), subsequently applying Pearson's correlation to the obtained regions, (2) nonparametric regression analysis relating the values in each pair of regions that showed significant correlation, and (3) nonparametric spatial regressions using three models designed for the purpose of this study. In the glaucoma group, a map that relates structural and functional damage was drawn. The strongest correlation with visual fields was observed in the peripheral nasal region of both superior and inferior hemigrids (r = 0.602 and r = 0.458, resp.). The estimated functions obtained with the nonparametric regressions provided the mean sensitivity that corresponds to each given macular thickness. These functions allowed for accurate characterization of the structure-function relationship. Both m...Continue Reading

References

Apr 15, 1991·American Journal of Ophthalmology·A Tuulonen, P J Airaksinen
Aug 15, 1989·American Journal of Ophthalmology·A HeijlG Lindgren
Jan 1, 1983·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P J Airaksinen, H I Alanko
Aug 1, 1994·Optometry and Vision Science : Official Publication of the American Academy of Optometry·A J VingrysG Smith
Jul 11, 2001·Optometry and Vision Science : Official Publication of the American Academy of Optometry·P G Spry, C A Johnson
Jan 14, 2003·Archives of Ophthalmology·David S GreenfieldRobert W Knighton
Jan 28, 2004·Investigative Ophthalmology & Visual Science·Donald C HoodRobert Ritch
Jun 14, 2006·Archives of Ophthalmology·Ronald S Harwerth, Harry A Quigley
Aug 11, 2006·The British Journal of Ophthalmology·F N KanadaniR Ritch
May 1, 2007·Ophthalmology·Rajul S ParikhRavi Thomas
Apr 2, 2008·Investigative Ophthalmology & Visual Science·Antonio FerrerasJulián García-Feijoo
Nov 5, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Neville DrasdoRachel V North
Jun 6, 2009·The British Journal of Ophthalmology·M Gonzalez-HernandezM Gonzalez de la Rosa
Nov 23, 2010·Investigative Ophthalmology & Visual Science·Yuriko KoteraNagahisa Yoshimura
Apr 12, 2011·The British Journal of Ophthalmology·Gadi WollsteinJoel S Schuman
Nov 23, 2011·Journal of Glaucoma·Whitney BolingVamsi Nukala
Feb 22, 2012·Clinical & Experimental Ophthalmology·Rizwan MalikDavid F Garway-Heath
Sep 22, 2012·Progress in Retinal and Eye Research·Donald C HoodRobert Ritch
Sep 29, 2012·The British Journal of Ophthalmology·Kyung Rim SungJoel S Schuman
May 11, 2013·Journal of Glaucoma·Keith MathersSanjay Asrani
Feb 4, 2014·American Journal of Ophthalmology·Tarek AlasilTeresa C Chen
Apr 8, 2014·Clinical Ophthalmology·Andrew J TathamFelipe A Medeiros
Mar 19, 2015·The British Journal of Ophthalmology·Blanca MonsalveMichele Iester
Apr 2, 2015·The British Journal of Ophthalmology·Soa KimMichael S Kook

❮ Previous
Next ❯

Software Mentioned

Humphrey
SITA
SPSS
GAUSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.