Maps of receptor binding parameters in the human brain--a kinetic analysis of PET measurements

European Journal of Nuclear Medicine
G BlomqvistC Halldin

Abstract

A kinetic method is described for the estimation of neuroreceptor density as well as the rate constants for association and dissociation of rapidly equilibrating radioligands. The method is exemplified by positron emission tomographic measurements of the human brain using 11C-raclopride, a D 2 dopamine receptor antagonist, and 11C-Ro 15-1788, a benzodiazepine receptor antagonist. Using a linear non iterative algorithm, regional binding characteristics were calculated and displayed pixel by pixel in brain maps. Data from repeated experiments on the same subject with different amounts of the unlabeled ligand were utilized. The binding characteristics were determined according to a two step procedure in which the time course of the free radioligand concentration was estimated from a reference region considered to be free of specific receptor binding sites. Alternative methods to determine the concentration of free radioligand are discussed.

References

Apr 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D F WongH N Wagner
Apr 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J S PerlmutterM J Welch
Oct 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S C HuangM E Phelps
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L FardeG Sedvall
Dec 1, 1984·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G Blomqvist
Feb 1, 1981·Journal of Computer Assisted Tomography·M BergströmL Widén

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Citations

Jul 1, 1995·European Journal of Nuclear Medicine·G BlomqvistK Wienhard
Dec 6, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Lia C LiefaardRob A Voskuyl
Jan 8, 2008·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Evan D MorrisWynne K Schiffer
Jan 1, 1991·Journal of Neuroscience Methods·A PerssonG Sedvall
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·E MatthewS M Paul
May 8, 2009·Physics in Medicine and Biology·Wenli WangJohn L Humm
Nov 26, 2010·Physics in Medicine and Biology·Gengsheng L ZengDan J Kadrmas
Mar 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J DelforgeA Syrota
Sep 18, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H ItoL Farde
May 18, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J DelforgeB Mazière
Dec 22, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A KoeppeM R Kilbourn
May 25, 2004·Nuclear Medicine Communications·Laszlo NovakLajos Tron
Jun 5, 1998·Acta Neurologica Scandinavica·I SavicB Gulyas
Jun 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·I SavicS Stone-Elander
Jul 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·I SavicG Blomqvist
Nov 27, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Cristian A SalinasRoger N Gunn
Oct 12, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ursula M H KlumpersAdriaan A Lammertsma
Feb 9, 2013·IEEE Transactions on Bio-medical Engineering·Ying Hsu, Andreas A Linninger
Apr 1, 1992·IEEE Transactions on Bio-medical Engineering·D R VeraR C Stadalnik
Jan 1, 1995·Journal of Psychopharmacology·A L Malizia, M P Richardson
Mar 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J DelforgeA Syrota
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J C PriceJ J Frost
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J E LittonS Pauli
Jan 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N A LassenP N Patsalos
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J DelforgeM Maziere
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·V A HolthoffD E Kuhl
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R A KoeppeD E Kuhl
Sep 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N A Lassen
Mar 31, 2016·World Journal of Radiology·Karlo J LizarragaAntonio A De Salles
Aug 2, 2018·EJNMMI Research·Thomas KoopmanMaqsood Yaqub
Apr 17, 2009·Nature Reviews. Microbiology·Alexander G MaierLeann Tilley

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