MARCH1-mediated MHCII ubiquitination promotes dendritic cell selection of natural regulatory T cells

The Journal of Experimental Medicine
Jaehak OhJeoung-Sook Shin

Abstract

Membrane-associated RING-CH1 (MARCH1) is an E3 ubiquitin ligase that mediates ubiquitination of MHCII in dendritic cells (DCs). MARCH1-mediated MHCII ubiquitination in DCs is known to regulate MHCII surface expression, thereby controlling DC-mediated T cell activation in vitro. However, its role at steady state or in vivo is not clearly understood. Here, we show that MARCH1 deficiency resulted in a substantial reduction in the number of thymus-derived regulatory T cells (T reg cells) in mice. A specific ablation of MHCII ubiquitination also significantly reduced the number of thymic T reg cells. Indeed, DCs deficient in MARCH1 or MHCII ubiquitination both failed to generate antigen-specific T reg cells in vivo and in vitro, although both exhibited an increased capacity for antigen presentation in parallel with the increased surface MHCII. Thus, MARCH1-mediated MHCII ubiquitination in DCs is required for proper production of naturally occurring T reg cells, suggesting a role in balancing immunogenic and regulatory T cell development.

References

Sep 1, 1996·The Journal of Experimental Medicine·C KurtsH Kosaka
Oct 20, 2004·The Journal of Experimental Medicine·Alena M Gallegos, Michael J Bevan
Feb 26, 2005·Nucleic Acids Research·Søren WarmingNeal G Copeland
Sep 1, 2006·Molecular and Cellular Biology·Søren WarmingNeal G Copeland
Jan 27, 2007·The EMBO Journal·Yohei MatsukiSatoshi Ishido
Feb 3, 2007·Nature Immunology·Wen LinTalal A Chatila
Feb 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dipica HaribhaiTalal A Chatila
Feb 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Aude De GassartEvelina Gatti
Apr 17, 2008·European Journal of Immunology·Virginie MilletRodolphe R Guinamard
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joy A WilliamsRichard J Hodes
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Anna I ProiettoLi Wu
Jul 1, 2009·The Journal of Experimental Medicine·Christian Koble, Bruno Kyewski
Aug 14, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomohisa BabaNaofumi Mukaida
Nov 18, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mari Ohmura-HoshinoSatoshi Ishido
Nov 26, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Danielle F AtibalentjaEmil R Unanue
May 1, 2010·Nature Immunology·Maria HinterbergerLudger Klein
Nov 3, 2010·Immunology and Cell Biology·Gerald WirnsbergerLudger Klein
Dec 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Danielle F AtibalentjaEmil R Unanue
Jan 12, 2011·The Journal of Experimental Medicine·Lina E TzeChristopher C Goodnow
Aug 19, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Günther BaravalleJeoung-Sook Shin
Feb 11, 2012·Nature Reviews. Immunology·Chyi-Song HsiehChan-Wang J Lio

Citations

Apr 30, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Fan Pan, Joseph Barbi
Mar 26, 2016·Cell Research·Hongbo Hu, Shao-Cong Sun
Jun 19, 2015·Immunological Reviews·Jaehak Oh, Jeoung-Sook Shin
Nov 29, 2013·Oncoimmunology·Erika VacchelliLorenzo Galluzzi
Feb 28, 2015·Nature Reviews. Immunology·Paul A Roche, Kazuyuki Furuta
May 11, 2016·The Journal of Experimental Medicine·Oliver BannardJason G Cyster
May 20, 2017·Critical Reviews in Biochemistry and Molecular Biology·Petra EbnerFumiyo Ikeda
Jan 27, 2018·The Journal of Cell Biology·Jaehak OhJeoung-Sook Shin
Dec 13, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tristan GalbasJacques Thibodeau
Jul 4, 2015·Immune Network·Jaehak Oh, Jeoung-Sook Shin
Jan 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lulu XieMingdong Zhao
Jun 15, 2013·Nature Reviews. Immunology·Maria Papatriantafyllou
Feb 23, 2019·Journal of Cellular and Molecular Medicine·Lulu XieMingdong Zhao
Aug 5, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Haiyin LiuJustine D Mintern
Aug 14, 2019·Frontiers in Immunology·Heng LinHong-Bing Shu
Jan 1, 2014·International Scholarly Research Notices·Tasleem SamjiRobert E Means
Sep 26, 2020·Frontiers in Immunology·Abdelilah MajdoubiJacques Thibodeau
Jan 13, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jaehak OhJeoung-Sook Shin
Oct 21, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jailal N AblackMark H Ginsberg
Dec 16, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hei Jung KimPaul A Roche

Related Concepts

MARCH1 protein, mouse
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Antigen-Presenting Cells
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