Marchantin A, a cyclic bis(bibenzyl ether), isolated from the liverwort Marchantia emarginata subsp. tosana induces apoptosis in human MCF-7 breast cancer cells

Cancer Letters
Wei-Jan HuangChia-Nan Chen

Abstract

Liverwort constituents have been reported to exert a broad spectrum of biological activities. In this study, we used a bioactivity-guided separation of an extract from the liverwort species Marchantia emarginata subsp. tosana to determine its anticancer activity. A high level of the active ingredient was isolated from this liverwort and its chemical structure was identified and characterized by various spectra. It was found to be identical to a well-known compound, marchantin A, a cyclic bisbibenzyl ether. However, no anticancer activities of this compound have previously been reported. We found that marchantin A efficiently induced cell growth inhibition in human MCF-7 breast cancer cells, with an IC(50) of 4.0microg/mL. Fluorescence microscopy and a Western blot analysis indicated that marchantin A actively induced apoptosis of MCF-7 cells. The levels of cleaved caspase-8, cleaved caspase-3, cleaved caspase-9, and cleaved poly (ADP ribose) polymerase (PARP) increased. However, the level of Bid markedly decreased in a dose- and time-dependent manner. We also evaluated the anticancer activities of marchantin A on the regulation of cell cycle regulators such as p21, p27, cyclin B1, and cyclin D1. The p21 and p27 gene expressions...Continue Reading

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Citations

Apr 5, 2011·Journal of Asian Natural Products Research·Li-Ning WangHong-Xiang Lou
Jun 2, 2012·Phytochemistry·Yoshinori AsakawaFumihiro Nagashima
May 10, 2011·Free Radical Biology & Medicine·Robert A FloydKirk R Maples
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Aug 18, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Samapika Nandy, Abhijit Dey
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Oct 12, 2017·Journal of Natural Products·Yoshinori Asakawa, Agnieszka Ludwiczuk

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