Marchantin C, a macrocyclic bisbibenzyl, induces apoptosis of human glioma A172 cells

Cancer Letters
Yanqiu ShiHong-Xiang Lou

Abstract

Macrocyclic bisbibenzyls, a class of characteristic components derived from liverworts, are attracting more and more attention because of their wide range of biological significance, including anti-bacterial, anti-fungus, anti-oxidation and cytotoxicity. Herein, we investigated the pro-apoptotic effect of marchantin C on human glioma A 172 cells. The results demonstrated that marchantin C conferred dose-dependent inhibitory effects onto cell growth, viability and colony formation ability of A 172 cells. Morphological observation and DNA laddering assay showed that marchantin C-treated A172 cells displayed outstanding apoptosis characteristics, such as nuclear fragmentation, the appearance of membrane-enclosed apoptotic bodies and DNA laddering fragment. Moreover, flow cytometric detection of phosphatidylserine externalization indicated that marchantin C-induced apoptosis occurred in a dose-dependent manner. RT-PCR and western blot assay further substantiated that marchantin C, as a promising pro-apoptotic agent, had strong effects to induce A172 cell apoptosis, suggesting that the action was achieved through up-regulating Bax and down-regulating Bcl-2.

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Citations

Apr 27, 2010·Acta Pharmacologica Sinica·Ai-hui XuHong-xiang Lou
Jan 1, 2009·Beilstein Journal of Organic Chemistry·Andreas SpeicherJürgen Kolz
Jun 2, 2012·Phytochemistry·Yoshinori AsakawaFumihiro Nagashima
Jul 22, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Lingmei SunHongxiang Lou
Mar 17, 2012·The Journal of Pharmacy and Pharmacology·Yafeng LvXingang Li
Jan 21, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xia XueXian-Jun Qu
Jun 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martin VollárDezső Csupor
Aug 18, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Samapika Nandy, Abhijit Dey
Oct 12, 2017·Journal of Natural Products·Yoshinori Asakawa, Agnieszka Ludwiczuk

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