Abstract
Macrocyclic bisbibenzyls, a class of characteristic components derived from liverworts, are attracting more and more attention because of their wide range of biological significance, including anti-bacterial, anti-fungus, anti-oxidation and cytotoxicity. Herein, we investigated the pro-apoptotic effect of marchantin C on human glioma A 172 cells. The results demonstrated that marchantin C conferred dose-dependent inhibitory effects onto cell growth, viability and colony formation ability of A 172 cells. Morphological observation and DNA laddering assay showed that marchantin C-treated A172 cells displayed outstanding apoptosis characteristics, such as nuclear fragmentation, the appearance of membrane-enclosed apoptotic bodies and DNA laddering fragment. Moreover, flow cytometric detection of phosphatidylserine externalization indicated that marchantin C-induced apoptosis occurred in a dose-dependent manner. RT-PCR and western blot assay further substantiated that marchantin C, as a promising pro-apoptotic agent, had strong effects to induce A172 cell apoptosis, suggesting that the action was achieved through up-regulating Bax and down-regulating Bcl-2.
References
Jan 1, 1997·British Medical Bulletin·A H Wyllie
Aug 28, 1998·Science·A Ashkenazi, V M Dixit
Mar 31, 2000·Experimental Cell Research·B Antonsson, J C Martinou
Jul 11, 2000·Natural Product Reports·D J NewmanK M Snader
Mar 13, 2001·Phytochemistry·Y Asakawa
Apr 28, 2001·Science·M C WeiS J Korsmeyer
Feb 1, 2003·Cancer Cell·John C Reed
Dec 10, 2003·The Lancet Oncology·Wei Hu, John J Kavanagh
Sep 14, 2004·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M HiraoT Tsujinaka
Nov 30, 2005·Journal of Internal Medicine·B Fadeel, S Orrenius
Dec 28, 2005·Journal of Natural Products·Liva HarinantenainaYoshinori Asakawa
Feb 7, 2006·Cancer Letters·Guanghui WangXinsheng Yao
Sep 29, 2006·Cancer Letters·Haseeb AhsanNihal Ahmad
Apr 24, 2007·Cancer Letters·Jeremy James Johnson, Hasan Mukhtar
Jul 5, 2007·Rapid Communications in Mass Spectrometry : RCM·Jie XingHongxiang Lou
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul R van GinkelArthur S Polans
Citations
Nov 29, 2011·Archives of Toxicology·A KunwarK I Priyadarsini
Apr 27, 2010·Acta Pharmacologica Sinica·Ai-hui XuHong-xiang Lou
Jan 1, 2009·Beilstein Journal of Organic Chemistry·Andreas SpeicherJürgen Kolz
Dec 4, 2012·Cancer Letters·Yanyan WangHongxiang Lou
Jun 2, 2012·Phytochemistry·Yoshinori AsakawaFumihiro Nagashima
Jun 28, 2011·European Journal of Pharmacology·Cui-cui SunXian-jun Qu
Dec 18, 2010·Life Sciences·Xia LiHongxiang Lou
Jul 22, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Lingmei SunHongxiang Lou
Jan 1, 2010·Cancer Letters·Shu-Xiang CuiJin-Xiang Han
Dec 20, 2008·Cancer Letters·Yan-qiu ShiHong-Xiang Lou
May 29, 2015·Pharmaceutical Biology·Zhongyi HuHuiqing Yuan
Mar 17, 2012·The Journal of Pharmacy and Pharmacology·Yafeng LvXingang Li
Jan 21, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xia XueXian-Jun Qu
Apr 1, 2014·Cancer Letters·Leilei NiuHongxiang Lou
Jun 19, 2016·European Journal of Medicinal Chemistry·Bin SunHong-Xiang Lou
May 18, 2018·ChemMedChem·Eduardo Hernández-VázquezLuis D Miranda
Jun 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martin VollárDezső Csupor
Aug 18, 2020·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Samapika Nandy, Abhijit Dey
Mar 7, 2017·PloS One·Xin WangQuanxi Wang
Jun 3, 2021·Plants·Ivana IvkovićDanka Bukvički
Oct 12, 2017·Journal of Natural Products·Yoshinori Asakawa, Agnieszka Ludwiczuk
Nov 17, 2021·Journal of Natural Products·Yoshinori AsakawaKenneth Yongabi Anchang